Heteroatom-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.

被引:0
|
作者
Lacombe, P
Deschênes, D
Dubé, D
Dubé, L
Gallant, M
Macdonald, D
Mastracchio, A
Perrier, H
Charleson, S
Huang, Z
Laliberté, F
Mancini, JA
Masson, P
Styhler, A
Nicholson, DW
Girard, Y
机构
[1] Merck Frosst Ctr Therapeut Res, Dept Med Chem, Pointe Claire, PQ H9R 4P8, Canada
[2] Merck Frosst Ctr Therapeut Res, Dept Biochem & Mol Biol, Pointe Claire, PQ H9R 4P8, Canada
[3] Merck Frosst Ctr Therapeut Res, Dept Pharmacol, Pointe Claire, PQ H9R 4P8, Canada
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
328-MEDI
引用
收藏
页码:U64 / U64
页数:1
相关论文
共 50 条
  • [1] Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors
    Lacombe, P
    Deschênes, D
    Dubé, D
    Dubé, L
    Gallant, M
    Macdonald, D
    Mastracchlo, A
    Perrier, H
    Charleson, S
    Huang, Z
    Laliberté, F
    Liu, S
    Mancini, JA
    Masson, P
    Salem, M
    Styhler, A
    Girard, Y
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (10) : 2608 - 2612
  • [2] Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors
    Lacombe, Patrick
    Chauret, Nathalie
    Claveau, David
    Day, Stephen
    Deschenes, Denis
    Dube, Daniel
    Gallant, Michel
    Girard, Yves
    Huang, Zheng
    Laliberte, France
    Levesque, Jean-Francois
    Liu, Susana
    Macdonald, Dwight
    Mancini, Joseph A.
    Masson, Paul
    Nicholson, Donald W.
    Nicoll-Griffith, Deborah A.
    Salem, Myriam
    Styhler, Angela
    Young, Robert N.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) : 5266 - 5269
  • [3] 8-Arylquinolines derivatives as potent PDE IV inhibitors
    Lacombe, P
    Deschênes, D
    Dubé, D
    Dubé, L
    Gallant, M
    Macdonald, D
    Mastracchio, A
    Perrier, H
    Huang, Z
    Laliberté, F
    Mancini, JA
    Masson, P
    Salem, M
    Nicholson, DW
    Girard, Y
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2672 - U2672
  • [4] The design and synthesis of bioavailable PDE IV inhibitors.
    Cox, PJ
    Fenton, G
    Newton, CG
    Page, K
    Palfreyman, MN
    Ratcliffe, AJ
    Smith, GF
    Souness, JE
    Stuttle, KAJ
    Thurairatnam, S
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 115 - MEDI
  • [5] The novel potent and selective PDE IV inhibitors
    Ukita, T
    Sugahara, M
    Terakawa, Y
    Kikkawa, H
    Wada, K
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 91 - MEDI
  • [6] Synthetic studies on selective type IV phosphodiesterase (PDE IV) inhibitors.
    Takayama, K
    Iwata, M
    Okamoto, Y
    Aoki, M
    Niwa, A
    Isomura, Y
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 245 - MEDI
  • [7] Design and synthesis of 2-substituted-3,4-dialkoxy-benzamides as PDE-IV inhibitors.
    Haddad, SN
    Maye, PV
    Gerster, JF
    Birmachu, W
    Scribner, LR
    Bulbulian, BJ
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U215 - U215
  • [8] Synthetic studies on selective type IV phosphodiesterase (PDE IV) inhibitors. II
    Hisamichi, H
    Takayama, K
    Iwata, M
    Kubota, H
    Kawano, N
    Aoki, M
    Isomura, Y
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 215 : U874 - U874
  • [9] Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.
    Edmondson, SD
    Mastracchio, A
    Duffy, JL
    Eiermann, GJ
    He, HB
    Leiting, B
    Leone, JF
    Lyons, KA
    Makarewicz, AM
    Patel, RA
    Petrov, A
    Wu, JK
    Thornberry, NA
    Weber, AE
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U218 - U218
  • [10] Synthesis of PDE IV inhibitors. First asymmetric synthesis of two of GlaxoSmithKline's highly potent Rolipram analogues
    Zhmurov, Petr A.
    Sukhorukov, Alexey Yu
    Chupakhin, Vladimir I.
    Khomutova, Yulia V.
    Ioffe, Sema L.
    Tartakovsky, Vladimir A.
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 11 (46) : 8082 - 8091