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Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

被引：8
|
作者：
Schmidt, B
Jiricek, J
Titz, A
Ye, GF
Parang, K
机构：
[1] Tech Univ Darmstadt, Inst Organ Chem & Biochem, D-64287 Darmstadt, Germany
[2] Univ Rhode Isl, Dept Biomed Sci, Kingston, RI 02881 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 16期
关键词：
SH2; domain; copper complex; ESR; peptide mimetic;
D O I：
10.1016/j.bmcl.2004.06.018
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4203 / 4206
页数：4
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