Metabolic Dysregulation Contributes to the Progression of Alzheimer's Disease

被引：96
|
作者：
Yan, Xu [1 ]
Hu, Yue [1 ]
Wang, Biyao [1 ]
Wang, Sijian [2 ]
Zhang, Xinwen [2 ]
机构：
[1] China Med Univ, Liaoning Prov Key Lab Oral Dis, Sch & Hosp Stomatol, VIP Dept, Shenyang, Peoples R China
[2] China Med Univ, Liaoning Prov Key Lab Oral Dis, Sch & Hosp Stomatol, Ctr Implant Dent, Shenyang, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2020年 / 14卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer’ s disease; glucose metabolism dysregulation; glycolysis dysfunction; TCA cycle and OXPHOS deficits; pentose phosphate pathway impairment; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; PENTOSE-PHOSPHATE-PATHWAY; CENTRAL-NERVOUS-SYSTEM; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPDH; BRAIN MITOCHONDRIAL DYSFUNCTION; GROWTH-FACTOR EXPRESSION; OXIDATIVE STRESS; GLUCOSE TRANSPORTERS; INTRANASAL INSULIN;
D O I：
10.3389/fnins.2020.530219
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis. In this review, we summarize metabolic alterations in aging brain and AD-related metabolic deficits associated with glucose metabolism dysregulation, glycolysis dysfunction, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS) deficits, and pentose phosphate pathway impairment. Additionally, we discuss recent treatment strategies targeting metabolic defects in AD, including their limitations, in an effort to encourage the development of novel therapeutic strategies.
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页数：20
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