Heterologous prime-boost vaccination

被引：351

作者：

Lu, Shan ^{[1
,2
,3
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, China US Vaccine Res Ctr, Nanjing 210029, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Infect Dis, Nanjing 210029, Peoples R China

[3] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; CELLULAR IMMUNE-RESPONSES; DNA PRIME; NEUTRALIZING ANTIBODIES; GP120; PROTEIN; RHESUS MACAQUES; COMBINATION DNA; SUBTYPE-B; IMMUNOGENICITY; PROTECTION;

D O I：

10.1016/j.coi.2009.05.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost. Heterologous prime-boost represents a new way of immunization and will stimulate better understanding on the immunological basis of vaccines.

引用

页码：346 / 351

页数：6

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