Molecular characterization of multidrug-resistant Streptococcus pneumoniae isolates in Korea

被引：16
|
作者：
Song, JH
Yang, JW
Jin, JH
Kim, SW
Kim, CK
Lee, H
Peck, KR
Kim, S
Lee, NY
Jacobs, MR
Appelbaum, PC
机构：
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis,Kangnam Ku, Seoul 135710, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Clin Pathol, Seoul 135710, South Korea
[3] Samsung Biomed Res Inst, Seoul, South Korea
[4] Asian Pacific Res Fdn Infect Dis, Seoul, South Korea
[5] Case Western Reserve Univ, Cleveland, OH 44106 USA
[6] Hershey Med Ctr, Hershey, PA USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2000年 / 38卷 / 04期
关键词：
D O I：
10.1128/JCM.38.4.1641-1644.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pulsed-field gel electrophoresis, ribotyping, and fingerprinting analysis of 22 invasive isolates of multidrug-resistant (MDR) pneumococci from Korea showed that 59 to 82% were genetically related. DNA sequencing of the PBP 2B gene showed relatively uniform alterations in nucleotides (5.4 to 7.8%) and amino acids (3.0 to 4.3%), while Asn-276-->Lys, Arg-285-->Cys and Ser-305-->Phe substitutions were unique to Korean MDR strains, suggesting the spread of a few epidemic clones of resistant pneumococci within Korea.
引用
收藏
页码：1641 / 1644
页数：4
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