Interaction of human recombination proteins Rad51 and Rad54

被引：102
|
作者：
Golub, EI [1 ]
Kovalenko, OV [1 ]
Gupta, RC [1 ]
Ward, DC [1 ]
Radding, CM [1 ]
机构：
[1] YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA
来源：
NUCLEIC ACIDS RESEARCH | 1997年 / 25卷 / 20期
关键词：
D O I：
10.1093/nar/25.20.4106
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cDNA for human protein HsRad54, which is a structural homolog of Saccharomyces cerevisiae recombination/repair protein Rad54, was cloned and expressed in Escherichia coli, As demonstrated by analysis in vitro and in vivo, HsRad54 protein interacts with human Rad51 recombinase. The interaction is mediated by the N-terminal domain of HsRad54 protein, which interacts with both free and DNA-bound HsRad51 protein.
引用
收藏
页码：4106 / 4110
页数：5
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