Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1

被引：11
|
作者：
Diallo, K
Oliveira, M
Moisi, D
Brenner, B
Wainberg, MA
Götte, M
机构：
[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, McGill AIDS Ctr, Montreal, PQ H3T 1E2, Canada
[2] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3T 1E2, Canada
[3] McGill Univ, Dept Expt Med, Montreal, PQ H3T 1E2, Canada
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 07期
关键词：
D O I：
10.1128/AAC.46.7.2254-2256.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.
引用
收藏
页码：2254 / 2256
页数：3
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