Executive Functions in Premanifest Huntington's Disease

被引：38

作者：

You, S. Christine ^{[1
]}

Geschwind, Michael D. ^{[1
]}

Sha, Sharon J. ^{[1
]}

Apple, Alexandra ^{[2
]}

Satris, Gabriella ^{[1
]}

Wood, Kristie A. ^{[1
]}

Johnson, Erica T. ^{[1
]}

Gooblar, Jonathan ^{[1
]}

Feuerstein, Jeanne S. ^{[1
]}

Finkbeiner, Steven ^{[1
,3
,4
,5
,6
]}

Kang, Gail A. ^{[1
]}

Miller, Bruce L. ^{[1
]}

Hess, Christopher P. ^{[2
]}

Kramer, Joel H. ^{[1
]}

Possin, Katherine L. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[3] Gladstone Inst Neurol Dis, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA USA

[5] Taube Koret Ctr Neurodegenerat Dis Res, San Francisco, CA USA

[6] Hellman Program Alzheimers Dis Res, San Francisco, CA USA

来源：

MOVEMENT DISORDERS | 2014年 / 29卷 / 03期

关键词：

Huntington's disease; executive function; working memory; striatal volume; disease burden; FLUENCY DEFICITS; WORKING-MEMORY; GENE-CARRIERS; MOUSE MODEL; DIAGNOSIS; DYSFUNCTION; PROGRESSION; DECLINES;

D O I：

10.1002/mds.25762

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundWe investigated the viability of psychometrically robust executive function measures as markers for premanifest Huntington's disease (HD). MethodsFifteen premanifest HD subjects and 42 controls were compared on the NIH EXAMINER executive function battery. This battery yields an overall executive composite score, plus working memory, cognitive control, and fluency scores that are measured on psychometrically matched scales. The scores were correlated with two disease markers, disease burden and striatal volumes, in the premanifest HD subjects. ResultsThe premanifest HD subjects scored significantly lower on the working memory score. The executive composite positively correlated with striatal volumes, and the working memory score negatively correlated with disease burden. The cognitive control and fluency scores did not differ between the groups or correlate significantly with the disease markers. ConclusionsThe NIH EXAMINER executive composite and working memory scores are sensitive markers of cognitive dysfunction, striatal volume, and disease burden in premanifest HD. (c) 2013 International Parkinson and Movement Disorder Society

引用

页码：405 / 409

页数：5

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