Suppression of IL-10 production by calcitriol in patients with multiple sclerosis

被引：14
|
作者：
Niino, Masaaki [1 ]
Fukazawa, Toshiyuki [2 ]
Miyazaki, Yusei [1 ,3 ]
Takahashi, Eri [1 ]
Minami, Naoya [3 ]
Amino, Itaru [3 ]
Fujiki, Naoto [3 ]
Doi, Shizuki [3 ]
Kikuchi, Seiji [3 ]
机构：
[1] Hokkaido Med Ctr, Dept Clin Res, Sapporo, Hokkaido 0630005, Japan
[2] Sapporo Neurol Clin, Sapporo, Hokkaido, Japan
[3] Hokkaido Med Ctr, Dept Neurol, Sapporo, Hokkaido 0630005, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 270卷 / 1-2期
关键词：
Vitamin D; Multiple sclerosis; Cytokine; IL-10; Disability; CD4(+) T-CELLS; 1,25-DIHYDROXYVITAMIN D-3; VITAMIN-D; DENDRITIC CELLS; DOWN-REGULATION; DIFFERENTIATION; EXPRESSION; MONOCYTES; SYSTEM; TRIAL;
D O I：
10.1016/j.jneuroim.2014.03.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated whether calcitriol (1,25-dihydroxyvitamin D) differentially modulates cytokine production by peripheral blood mononuclear cells from multiple sclerosis (MS) patients compared with that from healthy controls. In response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS), cytokine level in a calcitriol-added sample was normalized to that in a calcitriol-absent sample, and this relative unit was compared. The relative unit of IL-12/23(p40) in LPS-stimulation was higher in MS patients. Moreover, the relative unit of IL-10 in PHA-stimulation was lower in MS patients, and negatively correlated with the Expanded Disability Status Scale. The anti-inflammatory response to vitamin D may be reduced in MS. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：86 / 94
页数：9
相关论文
共 50 条
  • [1] Suppression of IL-10 production by calcitriol in patients with multiple sclerosis
    Niino, M.
    Fukazawa, T.
    Miyazaki, Y.
    Takahashi, E.
    Minami, N.
    Amino, I.
    Fujiki, N.
    Doi, S.
    Kikuchi, S.
    MULTIPLE SCLEROSIS JOURNAL, 2014, 20 : 331 - 331
  • [2] IL-10 Gene Polymorphisms and IL-10 Serum Levels in Patients with Multiple Sclerosis in Lithuania
    Masilionyte, Ugne
    Gedvilaite, Greta
    Kaikaryte, Kriste
    Vilkeviciute, Alvita
    Kriauciuniene, Loresa
    Glebauskiene, Brigita
    Balnyte, Renata
    Liutkeviciene, Rasa
    BRAIN SCIENCES, 2022, 12 (06)
  • [3] IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: preliminary findings
    Gelati, M
    Lamperti, E
    Dufour, A
    Corsini, E
    Venegoni, E
    Milanese, C
    Nespolo, A
    Salmaggi, A
    ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1997, 18 (04): : 191 - 194
  • [4] IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: preliminary findings
    M. Gelati
    E. Lamperti
    A. Dufour
    E. Corsini
    E. Venegoni
    C. Milanese
    A. Nespolo
    A. Salmaggi
    The Italian Journal of Neurological Sciences, 1997, 18 : 191 - 194
  • [5] Promoter polymorphism of IL-10 and severity of multiple sclerosis
    Luomala, M
    Lehtimäki, T
    Huhtala, H
    Ukkonen, M
    Koivula, T
    Hurme, M
    Elovaara, I
    ACTA NEUROLOGICA SCANDINAVICA, 2003, 108 (06): : 396 - 400
  • [6] Loss of IL-10 secretion by regulatory B lymphocytes in multiple sclerosis patients
    Laure Michel
    Nicolas Degauque
    Alexandra Garcia
    Marion Salou
    Annie Elong Ngono
    Jean-Paul Soulillou
    David Laplaud
    Sophie Brouard
    Journal of Translational Medicine, 9 (Suppl 2)
  • [7] Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse
    Gayo, A
    Mozo, L
    Suárez, A
    Tuñon, TB
    Lahoz, C
    Gutiérrez, C
    JOURNAL OF NEUROIMMUNOLOGY, 1998, 85 (02) : 122 - 130
  • [8] Effects of mitoxantrone on multiple sclerosis patients' lymphocyte subpopulations and production of immunoglobulin, TNF-alpha and IL-10
    Gbadamosi, J
    Bushmann, C
    Tessmer, W
    Moench, A
    Hagg, F
    Heesen, C
    EUROPEAN NEUROLOGY, 2003, 49 (03) : 137 - 141
  • [9] Interferon-β inhibits IL-10 production in activated human monocytes and stimulates IL-10 in T cells:: Implications for multiple sclerosis therapy
    Hamamcioglu, K
    Reder, AT
    ANNALS OF NEUROLOGY, 2003, 54 : S63 - S63
  • [10] INTERLEUKIN-10 (IL-10) PROMOTER POLYMORPHISM AT POSITION -1082 IN BULGARIAN PATIENTS WITH MULTIPLE SCLEROSIS
    Grigorov, Boncho G.
    Trenova, Anastasiya G.
    Slavov, Georgi S.
    Miteva, Lyuba D.
    Stanilova, Spaska A.
    COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2019, 72 (01): : 84 - 91
12345