Ulvan, a bioactive marine sulphated polysaccharide as a key constituent of hybrid biomaterials: A review

被引：139

作者：

Tziveleka, Leto-Aikaterini ^{[1
]}

Ioannou, Efstathia ^{[1
]}

Roussis, Vassilios ^{[1
]}

机构：

[1] Univ Athens, Sect Pharmacognosy & Chem Nat Prod, Dept Pharm, Athens 15771, Greece

来源：

CARBOHYDRATE POLYMERS | 2019年 / 218卷

关键词：

Ulvan; Sulphated polysaccharide; Hybrid materials; Biomedical applications; CELL-WALL POLYSACCHARIDES; NMR SPECTROSCOPIC CHARACTERIZATION; WATER-SOLUBLE POLYSACCHARIDES; GREEN SEAWEED; DRUG-DELIVERY; ANTIOXIDANT ACTIVITY; CHEMICAL CHARACTERISTICS; RIGIDA ULVALES; ENTEROMORPHA-INTESTINALIS; POLYELECTROLYTE COMPLEXES;

D O I：

10.1016/j.carbpol.2019.04.074

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Ulvan, a sulphated polysaccharide located in the cell walls of green algae that possesses unique structural properties albeit its repeating unit shares chemical affinity with glycosoaminoglycans, such as hyaluronan and chondroitin sulphate, has been increasingly studied over the years for applications in the pharmaceutical field. The increasing knowledge on ulvan's chemical properties and biological activities has triggered its utilization in hybrid materials, given its potential efficacy in biomedical applications. In the present review, the use of ulvan in the design of different biomaterials, including membranes, particles, hydrogels, 3D porous structures and nanofibers, is presented. The applications of these structures may vary from drug delivery to wound dressing or bone tissue engineering. In this context, general information regarding the structure and chemical variability, extraction processes, physicochemical properties, and biological activities of ulvan is reported.

引用

页码：355 / 370

页数：16