Mutation - Enzymes of evolutionary change

被引:101
|
作者
Radman, M [1 ]
机构
[1] Univ Paris 05, Fac Med Necker Enfants Malad, F-75730 Paris 15, France
关键词
D O I
10.1038/44738
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Although many mutations are harmful, some can help a population to adapt to environmental changes and enhance its chances of survival. Mutations have always been thought to be random, chance events, but the discovery of a set of enzymes known as mutases indicates that cells have mechanisms for generating them. The process needs to be tightly regulated, though, and is switched on only when the cell is under stress.
引用
收藏
页码:866 / +
页数:3
相关论文
共 50 条
  • [1] Enzymes of evolutionary change
    Miroslav Radman
    Nature, 1999, 401 : 866 - 869
  • [2] Evolutionary optimisation of enzymes
    Sutherland, JD
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (03) : 263 - 269
  • [3] EVOLUTIONARY DYNAMICS OF ENZYMES
    DEMETRIUS, L
    PROTEIN ENGINEERING, 1995, 8 (08): : 791 - 800
  • [4] Evolutionary mutation testing
    Dominguez-Jimenez, J. J.
    Estero-Botaro, A.
    Garcia-Dominguez, A.
    Medina-Bulo, I.
    INFORMATION AND SOFTWARE TECHNOLOGY, 2011, 53 (10) : 1108 - 1123
  • [5] Evolutionary molecular engineering for enzymes
    Tamakoshi, M
    Oshima, T
    SEIKAGAKU, 2000, 72 (05): : 376 - 379
  • [6] EVOLUTIONARY ENGINEERING OF RNA ENZYMES
    JOYCE, GF
    TSANG, J
    RAILLARD, SA
    DAI, XC
    PROTEIN ENGINEERING, 1995, 8 : 1 - 1
  • [7] Evolutionary Engineering of RNA Enzymes
    Joyce, G. F.
    Protein Engineering, 1995, 8
  • [8] The stabilization of equilibria in evolutionary game dynamics through mutation: mutation limits in evolutionary games
    Bauer, Johann
    Broom, Mark
    Alonso, Eduardo
    PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2019, 475 (2231):
  • [9] Evolutionary genomics - Splicing and evolutionary change
    Packer, A
    NATURE REVIEWS GENETICS, 2003, 4 (06) : 401 - 401
  • [10] Did Adaptive and Directed Mutation Evolve to Accelerate Stress-Induced Evolutionary Change? Introduction
    Saier, Milton H., Jr.
    JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 21 (1-2) : 5 - 7