Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers

被引:68
|
作者
Kumari, V
Cotter, PA
Mulligan, OF
Checkley, SA
Gray, NS
Hemsley, DR
Thornton, JC
Corr, PJ
Toone, BK
Gray, JA
机构
[1] Inst Psychiat, Dept Psychol Med, London SE5 8AF, England
[2] Inst Psychiat, Dept Psychol, London SE5 8AF, England
[3] Inst Psychiat, Dept Psychiat, London SE5 8AF, England
[4] Inst Psychiat, Sect Cognit Psychopharmacol, London SE5 8AF, England
基金
英国惠康基金;
关键词
d-amphetamine; dopamine; haloperidol; latent inhibition; psychoticism; schizophrenia;
D O I
10.1177/026988119901300411
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Latent inhibition (LI) refers to a retardation of learning about the consequences of a stimulus when that stimulus has been passively presented a number of times without reinforcement. Acute positive-symptom schizophrenics, normal volunteers who score high on questionnaire measures of schizotypy and non-patients or animals treated with dopamine agonists show reduced LI. Neuroleptic drugs, such as haloperidol, administered at low doses, potentiate LI and effectively reverse disruption of LI induced by dopamine agonists in animals. However, a high dose of haloperidol, administered on its own, has been found to reduce LI. We examined the effects on LI of acute oral administration of an indirect dopamine-agonist, d-amphetamine (5 mg), and a nonselective dopamine receptor antagonist, haloperidol (5 mg), in normal male volunteers, using an associative learning task. Replicating previous reports, we found that d-amphetamine reduced LI; haloperidol also reduced LI, but only in subjects who scored low on the Psychoticism. scale of the Eysenck Personality Questionnaire. In a subsequent study no effect was found of 2 mg oral haloperidol administration on LI. The effect of 5 mg haloperidol on LI is interpreted as similar to that observed with a high dose of haloperidol in rats.
引用
收藏
页码:398 / 405
页数:8
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