Antisense peptide interactions studied by electrospray ionization mass spectrometry

被引：1
|
作者：
Madhusudanan, KP [1 ]
Katti, SB [1 ]
Haq, W [1 ]
Misra, PK [1 ]
机构：
[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India
来源：
JOURNAL OF MASS SPECTROMETRY | 2000年 / 35卷 / 02期
关键词：
antisense peptides; electrospray ionization mass spectrometry; non-covalent complexes; heterodimers; interactions;
D O I：
10.1002/(SICI)1096-9888(200002)35:2<237::AID-JMS934>3.3.CO;2-V
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Non-covalent interactions between met- and leu-enkephalins and their antisense peptides were studied by electrospray ionization mass spectrometry. Mixtures of sense and antisense peptides gave both the corresponding homodimers and heterodimers, The relative abundance ratios of the heterodimer to that of the homodimer of the sense peptide and the relative stability constants of the heterodimers were compared with the corresponding values from mixtures of the sense peptides and a control peptide. The results show that there is a preferential interaction between the sense and antisense peptides compared with that between the sense and control peptides. Copyright (C) 2000 John Wiley & Sons, Ltd.
引用
收藏
页码：237 / 241
页数：5
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