Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD

被引：39
|
作者：
Vanderheyden, William M. [1 ]
Poe, Gina R. [1 ]
Liberzon, Israel [1 ]
机构：
[1] Univ Michigan, Ann Arbor, MI 48109 USA
来源：
EXPERIMENTAL BRAIN RESEARCH | 2014年 / 232卷 / 05期
关键词：
Sleep; PTSD; Locus coeruleus; POSTTRAUMATIC-STRESS-DISORDER; CORTICOTROPIN-RELEASING-FACTOR; LOCUS-COERULEUS NEURONS; LONG-TERM DEPRESSION; SPATIAL WORKING-MEMORY; HIPPOCAMPAL-PREFRONTAL SYNCHRONY; INDUCED TAU PHOSPHORYLATION; FERRET LATERAL GENICULATE; SEXUAL ASSAULT SURVIVORS; COMBAT-RELATED PTSD;
D O I：
10.1007/s00221-014-3890-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep-wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC activity may be playing a key role in symptom formation in PTSD via sleep dysregulation and suppression of hippocampal bidirectional plasticity.
引用
收藏
页码：1575 / 1584
页数：10
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