A GREENER SYNTHESIS TECHNOLOGY FOR LOMEFLOXACIN HYDROCHLORIDE

被引：1

作者：

Cheng, Shuiming ^{[1
]}

Zhu, Shengdong ^{[1
]}

Wu, Yuanxin ^{[1
]}

Chen, Rui ^{[1
]}

Yu, Ziniu ^{[2
]}

Zhang, Xinya ^{[3
]}

机构：

[1] Wuhan Inst Technol, Sch Chem Engn & Pharm, Hubei Key Lab Novel Chem Reactor & Green Chem Tec, Minist Educ,Key Lab Green Chem Proc, Wuhan 430073, Peoples R China

[2] Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Peoples R China

[3] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou, Guangdong, Peoples R China

来源：

CHEMICAL ENGINEERING COMMUNICATIONS | 2009年 / 196卷 / 08期

关键词：

Ionic liquid; Lomefloxacin hydrochloride; Synthesis; IONIC LIQUIDS;

D O I：

10.1080/00986440902743794

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Lomefloxacin ethyl ester was prepared from 2,3,4-trifluoroaniline in ionic liquid in a one-pot procedure by condensation with EMME (ethoxymethylenemalonic diethyl ester), cyclization, ethylation, and condensation with 2-methyl piperazine. After its hydrolysis and salifying with hydrochloric acid, lomefloxacin hydrochloride was obtained with an overall yield of 58.4%. Compared with current lomefloxacin hydrochloride synthesis technology, this approach simplified its synthesis procedures, shortened its synthesis time, and eliminated the usage of volatile organic solvents.

引用

页码：901 / 905

页数：5

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