GluR4c, an alternative splicing isoform of GluR4, expressed in the adult human brain* is abundantly

被引：12

作者：

Kawahara, Y

Ito, K

Sun, H

Ito, M

Kanazawa, I

Kwak, S

机构：

[1] Univ Tokyo, Dept Neurol, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Natl Inst Neurosci, Natl Ctr Neurol & Psychiat, Kodaira, Tokyo 1878502, Japan

[3] Japan Sci & Technol Corp, SORST, Natl Ctr Neurol & Psychiat, Kodaira, Tokyo 1878502, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2004年 / 127卷 / 1-2期

关键词：

AMPA receptor; GluR subunit; alternative splicing; quantitative RT-PCR; PDZ domain;

D O I：

10.1016/j.molbrainres.2004.05.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report the cloning of human GluR4c, an alternative splicing isoform of GluR4. Similar to rodent and chick GluR4c mRNA, human GluR4c had a 113-bp insert containing a stop codon, resulting in a short C terminus. The expression of human GluR4c was widespread in the brain, and was upregulated with development in the cerebellum and cerebral cortex where the level of it was about 30% of total GluR4 mRNA in adult stage. The GluR4 subunit may play a pivotal role in regulating channel properties as well as trafficking of U-amino-3hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in the adult human brain. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：150 / 155

页数：6

共 15 条

[1] Human GluR6c, a functional splicing variants of GluR6, is mainly expressed in non-nervous cells
Barbon, Alessandro
Gervasoni, Annalisa
LaVia, Luca
Orlandi, Cesare
Jaskolski, Frederic
Perrais, David
Barlati, Sergio
[J]. NEUROSCIENCE LETTERS, 2008, 434 (01) : 77 - 82
[2] PROTEIN KINASE C-DEPENDENT AND INDEPENDENT SIGNALING PATHWAYS REGULATE SYNAPTIC GluR1 AND GluR4 AMPAR SUBUNITS DURING IN VITRO CLASSICAL CONDITIONING
Zheng, Z.
Keifer, J.
[J]. NEUROSCIENCE, 2008, 156 (04) : 872 - 884
[3] Phosphorylation of GluR4 AMPA-type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons
Carvalho, AL
Correia, S
Faro, CJ
Duarte, CB
Carvalho, AP
Pires, EMV
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 15 (03) : 465 - 474
[4] Protein kinase Cγ associates directly with the GluR4 α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit -: Effect on receptor phosphorylation
Correia, SS
Duarte, CB
Faro, CJ
Pires, EV
Carvalho, AL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) : 6307 - 6313
[5] A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain
Mitsui, S
Tsuruoka, N
Yamashiro, K
Nakazato, H
Yamaguchi, N
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 260 (03): : 627 - 634
[6] Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain
Zhang, CG
Meng, FW
Wang, CL
Guo, HY
Fan, M
Liu, SJ
Zhou, RP
He, FH
[J]. MOLECULAR BRAIN RESEARCH, 2004, 130 (1-2): : 68 - 80
[7] Differential expression and splicing isoform analysis of human Tcf-4 transcription factor in brain tumors
Howng, SL
Huang, FH
Hwang, SL
Lieu, AS
Sy, WD
Wang, CH
Hong, YR
[J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2004, 25 (06) : 1685 - 1692
[8] A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells
Magistrelli, G
Jeannin, P
Herbault, N
de Coignac, AB
Gauchat, JF
Bonnefoy, JY
Delneste, Y
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1999, 29 (11) : 3596 - 3602
[9] TRPM4 Drives Cerebral Edema by Switching to Alternative Splicing Isoform After Experimental Traumatic Brain Injury
Zhang, Lihan
Li, Chaojie
He, Yijing
Kuang, Chenghao
Qiu, Xiancheng
Gu, Long
Wu, Jinpeng
Pang, Jinwei
Zhang, Lifang
Xie, Bingqing
Peng, Jianhua
Yin, Shigang
Jiang, Yong
[J]. JOURNAL OF NEUROTRAUMA, 2023, 40 (15-16) : 1779 - 1795
[10] An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer
Wu, Di
Matsushita, Kazuyuki
Matsubara, Hisahiro
Nomura, Fumio
Tomonaga, Takeshi
[J]. INTERNATIONAL JOURNAL OF CANCER, 2011, 128 (05) : 1018 - 1030

← 1 2 →