COMPARISON OF INTRA-ARTICULAR SHAM AND VEHICLE INJECTION FROM A PHASE 2B TRIAL OF SM04690, A SMALL-MOLECULE WNT INHIBITOR, FOR KNEE OSTEOARTHRITIS

被引：1
|
作者：
Yazici, Y. [1 ]
Tambiah, J. [1 ]
Swearingen, C. [1 ]
Kennedy, S. [1 ]
Strand, V. [2 ]
Cole, B. [3 ]
Hochberg, M. [4 ]
Bannuru, R. [5 ]
McAlindon, T. [5 ]
机构：
[1] Samumed, San Diego, CA USA
[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA
[3] Rush Univ, Midwest Orthopaed, Chicago, IL 60612 USA
[4] Univ Maryland, Baltimore, MD 21201 USA
[5] Tufts Univ, Med Ctr, Boston, MA 02111 USA
来源：
OSTEOARTHRITIS AND CARTILAGE | 2019年 / 27卷
关键词：
D O I：
10.1016/j.joca.2019.02.605
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
340
引用
收藏
页码：S241 / S242
页数：2
相关论文
共 50 条
  • [1] COMPARISON OF INTRA-ARTICULAR SHAM AND VEHICLE INJECTIONS FROM A PHASE 2B TRIAL OF SM04690, A SMALL-MOLECULE WNT PATHWAY INHIBITOR FOR KNEE OSTEOARTHRITIS
    Yazici, Yusuf
    Tambiah, Jeyanesh
    Swearingen, Christopher
    Kennedy, Sarah
    Strand, Vibeke
    Cole, Brian
    Hochberg, Marc
    Bannuru, Raveendhara
    Mcalindon, Timothy
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 494 - 494
  • [2] RESULTS FROM A PHASE 2B TRIAL OF SM04690, A NOVEL INTRA-ARTICULAR WNT PATHWAY INHIBITOR FOR THE TREATMENT OF KNEE OSTEOARTHRITIS
    Yazici, Y.
    Mcalindon, T.
    Gibofsky, A.
    Lane, N.
    Lattermann, C.
    Skrepnik, N.
    Swearingen, C.
    Difrancesco, A.
    Tambiah, J.
    Hochberg, M.
    OSTEOPOROSIS INTERNATIONAL, 2019, 30 : S183 - S184
  • [3] EFFICACY AND SAFETY FROM A PHASE 2B TRIAL OF SM04690, A NOVEL, INTRA-ARTICULAR, WNT PATHWAY INHIBITOR FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
    Yazici, Y.
    McAlindon, T. E.
    Gibofsky, A.
    Lane, N. E.
    Latterman, C.
    Skrepnik, N.
    Swearingen, C. J.
    DiFrancesco, A.
    Tambiah, J. R.
    Hochberg, M. C.
    OSTEOARTHRITIS AND CARTILAGE, 2019, 27 : S503 - S503
  • [4] EFFICACY AND SAFETY FROM A PHASE 2B TRIAL OF SM04690, A NOVEL, INTRA-ARTICULAR WNT PATHWAY INHIBITOR FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
    Yazici, Yusuf
    McAlindon, Timothy
    Gibofsky, Allan
    Lane, Nancy
    Latterman, Christian
    Skrepnik, Nebojsa
    Swearingen, Chris
    DiFrancesco, Anita
    Tambiah, Jeyanesh
    Hochberg, Marc
    Grifman, Mirta
    JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2019, 25 : S12 - S12
  • [5] EFFICACY AND SAFETY FROM A PHASE 2B TRIAL OF SM04690, A NOVEL INTRA-ARTICULAR WNT PATHWAY INHIBITOR FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
    Yazici, Yusuf
    Mcalindon, Timothy
    Gibofsky, Allan
    Lane, Nancy
    Lattermann, Christian
    Skrepnik, Nebojsa
    Swearingen, Christopher
    Difrancesco, Anita
    Tambiah, Jeyanesh
    Hochberg, Marc
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 519 - 519
  • [6] PROSPECTIVE COMPARISON OF INTRA-ARTICULAR SHAM VS. PLACEBO INJECTIONS: DATA FROM A RANDOMIZED, CONTROLLED PHASE 2B TRIAL OF SM04690, A WNT PATHWAY INHIBITOR FOR KNEE OSTEOARTHRITIS
    Yazici, Y.
    Tambiah, J.
    Swearingen, C.
    Kennedy, S.
    Strand, V.
    Cole, B.
    Hochberg, M.
    Bannuru, R.
    McAlindon, T.
    OSTEOPOROSIS INTERNATIONAL, 2019, 30 : S519 - S520
  • [7] Discovery of an Intra-Articular Injection Small Molecule Inhibitor of the Wnt Pathway (SM04690) As a Potential Disease Modifying Treatment for Knee Osteoarthritis
    Barroga, Charlene
    Hu, Yong
    Deshmukh, Vishal
    Hood, John
    ARTHRITIS & RHEUMATOLOGY, 2015, 67
  • [8] A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee
    Deshmukh, V.
    Hu, H.
    Barroga, C.
    Bossard, C.
    Kc, S.
    Dellamary, L.
    Stewart, J.
    Chiu, K.
    Ibanez, M.
    Pedraza, M.
    Seo, T.
    Do, L.
    Cho, S.
    Cahiwat, J.
    Tam, B.
    Tambiah, J. R. S.
    Hood, J.
    Lane, N. E.
    Yazici, Y.
    OSTEOARTHRITIS AND CARTILAGE, 2018, 26 (01) : 18 - 27
  • [9] Reducing Heterogeneity in OA Clinical Trials: Data from a Phase 2 Study of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor in Knee Osteoarthritis
    Conaghan, Philip G.
    DiFrancesco, Anita
    Swearingen, Christopher J.
    Kennedy, Sarah
    Simsek, Ismail
    Tambiah, Jeymi
    Yazici, Yusuf
    ARTHRITIS & RHEUMATOLOGY, 2017, 69
  • [10] Lorecivivint (SM04690), an Intra-articular, Small-Molecule CLK/DYRK Inhibitor That Modulates the Wnt Pathway, as a Potential Treatment for Meniscal Injuries
    Seo, Timothy
    Deshmukh, Vishal
    Yazici, Yusuf
    ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 3087 - 3088
12345