Inhibition of Peroxidase-Catalyzed Iodination by Cephalosporins: Metallo-β-Lactamase-Induced Antithyroid Activity of Antibiotics

被引：13

作者：

Tamilselvi, A. ^{[1
]}

Mugesh, Govindasamy ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

CHEMMEDCHEM | 2009年 / 4卷 / 04期

关键词：

antibiotics; antithyroid drugs; drug resistance; metallo-beta-lactamase; peroxidase; RADICAL MECHANISM; RESISTANCE; HYPOPROTHROMBINEMIA; DRUGS;

D O I：

10.1002/cmdc.200800371

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Broad-spectrum antibiotics with heterocyclic side chains strongly Inhibit peroxidase-catalyzed ¡odination in the presence of metallo-β- lactamase. This suggests that antibiotic resistance due to hydrolysis of the β-lactam ring in antibiotics would have negative effects on thyroid activity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：512 / 516

页数：5

共 21 条

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