Engineering synergy in biotechnology

被引：113

作者：

Nielsen, Jens ^{[1
,2
,3
]}

Fussenegger, Martin ^{[11
]}

Keasling, Jay ^{[1
,4
,5
,6
,7
,8
]}

Lee, Sang Yup ^{[9
,10
]}

Liao, James C. ^{[12
]}

Prather, Kristala ^{[13
,14
]}

Palsson, Bernhard ^{[1
]}

机构：

[1] Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, Horsholm, Denmark

[2] Chalmers Univ Technol, Dept Chem & Biol Engn, S-41296 Gothenburg, Sweden

[3] Royal Inst Technol, Sci Life Lab, Solna, Sweden

[4] Joint Bioenergy Inst, Emeryville, CA USA

[5] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[7] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA

[8] Synthet Biol Engn Res Ctr SynBERC, Berkeley, CA USA

[9] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Taejon 305701, South Korea

[10] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[11] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland

[12] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA USA

[13] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[14] Synthet Biol Engn Res Ctr SynBERC, Cambridge, MA USA

来源：

NATURE CHEMICAL BIOLOGY | 2014年 / 10卷 / 05期

关键词：

SYNTHETIC BIOLOGY; CONSTRUCTION; SWITCH;

D O I：

10.1038/nchembio.1519

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biotechnology is a central focus in efforts to provide sustainable solutions for the provision of fuels, chemicals and materials. On the basis of a recent open discussion, we summarize the development of this field, highlighting the distinct but complementary approaches provided by metabolic engineering and synthetic biology for the creation of efficient cell factories to convert biomass and other feedstocks to desired chemicals.

引用

页码：319 / 322

页数：4

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