WONOEP appraisal: Imaging biomarkers in epilepsy

被引：19

作者：

van Vliet, Erwin A. ^{[1
]}

Dedeurwaerdere, Stefanie ^{[2
]}

Cole, Andrew J. ^{[3
]}

Friedman, Alon ^{[4
,5
]}

Koepp, Matthias J. ^{[6
]}

Potschka, Heidrun ^{[7
]}

Immonen, Riikka ^{[8
]}

Pitkanen, Asla ^{[8
]}

Federico, Paolo ^{[9
,10
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Neuro Pathol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Antwerp, Dept Translat Neurosci, Antwerp, Belgium

[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[4] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, Dept Brain & Cognit Sci, Beer Sheva, Israel

[5] Dalhousie Univ, Dept Med Neurosci, Halifax, NS, Canada

[6] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London, England

[7] Ludwig Maximilians Univ Munchen, Inst Pharmacol Toxicol & Pharm, Munich, Germany

[8] Univ Eastern Finland, Dept Neurobiol, AI Virtanen Inst Mol Sci, Kuopio, Finland

[9] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB, Canada

[10] Univ Calgary, Hotchkiss Brain Inst, Dept Radiol, Calgary, AB, Canada

来源：

EPILEPSIA | 2017年 / 58卷 / 03期

基金：

加拿大健康研究院; 芬兰科学院;

关键词：

Biomarker; Epileptogenesis; Traumatic brain injury; Imaging; Inflammation; Blood-brain barrier; BLOOD-BRAIN-BARRIER; TEMPORAL-LOBE EPILEPSY; MAGNETIC-RESONANCE-SPECTROSCOPY; SIMULTANEOUS INTRACRANIAL EEG; POSITRON-EMISSION-TOMOGRAPHY; P-GLYCOPROTEIN FUNCTION; PROTON MR SPECTROSCOPY; IN-VIVO; STATUS EPILEPTICUS; LANGUAGE LATERALIZATION;

D O I：

10.1111/epi.13621

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood-brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organized in 2015 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). Here we present an extended summary of the discussed issues and provide an overview of the current state of knowledge regarding the biomarker potential of different neuroimaging approaches for epilepsy.

引用

页码：315 / 330

页数：16

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