MRI Reveals Brain Abnormalities in Drug-Naive Parkinson's Disease

被引：13

作者：

Planetta, Peggy J. ^{[1
]}

McFarland, Nikolaus R. ^{[2
,3
]}

Okun, Michael S. ^{[2
,3
,4
]}

Vaillancourt, David E. ^{[1
,2
,5
]}

机构：

[1] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Neurol, Gainesville, FL 32611 USA

[3] Univ Florida, Ctr Movement Disorders & Neurorestorat, Gainesville, FL 32611 USA

[4] Univ Florida, Dept Neurosurg, Gainesville, FL 32611 USA

[5] Univ Florida, Dept Biomed Engn, Gainesville, FL 32611 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2014年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

diffusion tensor imaging; functional magnetic resonance imaging; fMRI; parkinsonism; grip force; subtype; de novo; movement; BASAL GANGLIA NUCLEI; SUBSTANTIA-NIGRA; FORCE AMPLITUDE; DIFFUSION; LEVODOPA; ACTIVATION; PATHOLOGY; SUBTYPES; CORTEX; FMRI;

D O I：

10.1249/JES.0000000000000003

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Most brain studies of Parkinson's disease (PD) focus on patients who are already taking antiparkinsonian medication. This makes it difficult to isolate the effects of disease from those of treatment. We review magnetic resonance imaging evidence supporting the hypothesis that early-stage untreated PD patients have structural and functional abnormalities in the brain, some of which are related to motor symptoms.

引用

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页码：12 / 22

页数：11

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