Ancient origin and complex evolution of porcine endogenous retroviruses

被引：6
|
作者：
Chen, Yicong [1 ,2 ,3 ]
Chen, Mingyue [4 ]
Duan, Xiaoyan [1 ,3 ]
Cui, Jie [1 ,2 ]
机构：
[1] Chinese Acad Sci, Ctr Biosafety Mega Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China
[2] Chinese Acad Sci, CAS Key Lab Mol Virol & Immunol, Inst Pasteur Shanghai, Shanghai 200031, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Hubei Univ Technol, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Key Lab Fermentat Engn, Minist Educ, Wuhan 430068, Peoples R China
来源：
BIOSAFETY AND HEALTH | 2020年 / 2卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Porcine endogenous retrovirus; Evolution; Origin; Genomic rearrangement; Cross-species transmission; LONG TERMINAL REPEATS; MOLECULAR CLOCK; SEQUENCES; PERV; IDENTIFICATION; REPLICATION; PERFORMANCE; INFECTION; ENHANCER; TRIAL;
D O I：
10.1016/j.bsheal.2020.03.003
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood. In this study, we in silico mined 14 pig genomes and other available 304 mammalian genomes, which led to the documentation of 185 full-length PERVs or PERV-like sequences. Notably, we found that lesser Egyptian jerboa (Jaculus jaculus), rock hyrax (Procavia capensis) and eight Muridae species all harbored ancestral PERV-like sequences, indicative of ancient cross-species transmission events from none-porcine species to pigs. We also revealed that 11 genomic rearrangement events were mediated via PERVs, during the process of porcine evolution. In conclusion, these new findings help us to understand the complex evolution of the modern PERVs.(c) 2020 Chinese Medical Association Publishing House. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页码：142 / 151
页数：10
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