Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells

被引：5
|
作者：
Walos, S [1 ]
Szary, J [1 ]
Szala, S [1 ]
机构：
[1] Marie Sklodowska Curie Mem Inst, Ctr Oncol, Dept Biol Mol, PL-44101 Gliwice, Poland
来源：
ACTA BIOCHIMICA POLONICA | 1999年 / 46卷 / 04期
关键词：
interleukin; 10; antiangiogenic effect; B16(F10) murine melanoma;
D O I：
10.18388/abp.1999_4120
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.
引用
收藏
页码：967 / 970
页数：4
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