Comparison of alfaxalone, ketamine and thiopental for anaesthetic induction and recovery in Thoroughbred horses premedicated with medetomidine and midazolam

Reasons for performing studyThere is limited information on clinical use of the new injectable anaesthetic agent alfaxalone in Thoroughbred horses. ObjectivesTo compare anaesthetic induction and recovery characteristics and cardiopulmonary responses between alfaxalone, ketamine and thiopental in Thoroughbred horses premedicated with medetomidine and midazolam. Study designRandomised blinded experimental cross-over study. MethodsSix Thoroughbred horses were anaesthetised 3 times with alfaxalone 1mg/kg bwt, ketamine 2.5mg/kg bwt or thiopental 4mg/kg bwt after premedication with medetomidine 6g/kg bwt and midazolam 20g/kg bwt. Qualities of anaesthetic induction and recovery were scored on a scale of 1 (poor) to 5 (excellent). Induction time and recovery time were recorded. Cardiopulmonary values (heart rate, respiratory rate, arterial blood pressures, and arterial blood gases) were recorded throughout anaesthesia. Data were analysed with nonparametric methods. ResultsThe anaesthetic induction (P=0.2) and recovery (P=0.1) quality scores (median, range) were not different amongst protocols and were 4.0, 3-5; 5.0, 4-5; 4.5, 3-5; and 4.5, 3-5; 3.5, 2-5; 4.0, 2-5 for alfaxalone, ketamine and thiopental, respectively. Induction time for ketamine (67, 53-89s) was significantly longer than that for alfaxalone (49, 40-51s, P=0.01) and thiopental (48, 43-50s, P=0.01). Time to standing for alfaxalone (44, 40-63min, P=0.01) and thiopental (39, 30-58min, P=0.01) was significantly longer than that for ketamine (25, 18-26min). Cardiovascular values were maintained within the clinically acceptable level throughout anaesthesia. Respiratory rate significantly decreased during anaesthesia for all 3 drugs; however, spontaneous breathing did not disappear, and PaCO2 values were maintained at approximately 50mmHg. ConclusionsAll 3 drugs showed similar effects in relation to anaesthetic induction and recovery qualities and cardiopulmonary responses. However, alfaxalone and thiopental prolonged recovery time compared with ketamine. The Summary is available in Chinese - see Supporting information