Conditional biochemical recurrence-free survival after radical prostatectomy in patients with high-risk prostate cancer

被引:3
|
作者
Park, Sung-Woo [1 ,2 ]
Hwang, Dae Sung [2 ]
Song, Won Hoon [1 ]
Nam, Jong Kil [1 ]
Lee, Hyun Jung [3 ]
Chung, Moon Kee [1 ,2 ]
机构
[1] Pusan Natl Univ, Dept Urol, Yangsan Hosp, Yangsan, South Korea
[2] Pusan Natl Univ, Dept Urol, Pusan, South Korea
[3] Pusan Natl Univ, Dept Pathol, Yangsan Hosp, Yangsan, South Korea
关键词
Biochemical recurrence; Conditional survival; Prostatic neoplasms; Radical prostatectomy; PROBABILITY; CARCINOMA; MORTALITY;
D O I
10.1016/j.prnil.2020.07.004
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background: Conditional survival is defined as the likelihood of subsequent survival given the precondition of having already survived a certain length of time. Most analyses of conditional survival in prostate cancer are not clinically applicable because they do not analyze outcomes conditioned on the durability of cure after treatment. We evaluated the conditional probability of biochemical recurrence (BCR)-free survival (C-BCRFS) after radical prostatectomy (RP) for prostate cancer according to the National Comprehensive Cancer Network risk classification and prognostic factors in patients who survived several years without BCR. Methods: Between January 2009 and December 2018, 877 patients with complete clinicopathologic and follow-up data were included. Using the Kaplan-Meier estimation, the probabilities of C-BCRFS after RP were estimated in patients who did not experience BCR at 0-4 years. C-BCRFS was analyzed according to the National Comprehensive Cancer Network risk classification and compared using the log-rank test. Prognostic factors at each year without BCR were evaluated using multivariable Cox regression analysis. Results: The median follow-up duration and patient age were 48 months and 67 years, respectively. As the BCR-free interval increased (baseline, 1, 2, 3, and 4 years after RP), the 5-year C-BCRFS rates improved marginally (74.8%, 83.2%, 89.1%, 93.6%, and 98.5%, respectively). However, the 5-year C-BCRFS rates in the high/very high-risk group rose from 54.0% at baseline to 67.6%, 80.3%, 88.6, and 97.8% after 1-4 years free of BCR, respectively. In patients with a BCR-free duration more than 1 year, only seminal vesicle invasion and pathological Gleason score were significant predictive factors of BCR thereafter. Conclusion: In the high/very high-risk group, the C-BCRFS markedly improved as the interval without BCR increased. In patients who were BCR-free for several years, seminal vesicle invasion and pathological Gleason score were prognostic factors of continued BCRFS. This is useful not only for patient counseling but also to optimize postoperative follow-up strategies. (C) 2020 Asian Pacific Prostate Society. Published by Elsevier B.V.
引用
收藏
页码:173 / 177
页数:5
相关论文
共 50 条
  • [1] Biochemical recurrence-free survival and pathological outcomes after radical prostatectomy for high-risk prostate cancer
    Beauval, Jean-Baptiste
    Roumiguie, Mathieu
    Filleron, Thomas
    Benoit, Thibaut
    de la Taille, Alexandre
    Malavaud, Bernard
    Salomon, Laurent
    Soulie, Michel
    Ploussard, Guillaume
    [J]. BMC UROLOGY, 2016, 16
  • [2] Biochemical recurrence-free survival and pathological outcomes after radical prostatectomy for high-risk prostate cancer
    Jean-Baptiste Beauval
    Mathieu Roumiguié
    Thomas Filleron
    Thibaut Benoit
    Alexandre de la Taille
    Bernard Malavaud
    Laurent Salomon
    Michel Soulié
    Guillaume Ploussard
    [J]. BMC Urology, 16
  • [3] Preoperative Predictors of Biochemical Recurrence-Free Survival in High-Risk Prostate Cancer Following Radical Prostatectomy
    Nkengurutse, Gerard
    Tian, Feng
    Jiang, Sixiong
    Wang, Qi
    Wang, Ying
    Sun, Weibing
    [J]. FRONTIERS IN ONCOLOGY, 2020, 10
  • [4] Pathological outcomes and biochemical recurrence-free survival after radical prostatectomy for high-risk prostate cancer in the Indian population
    Bijalwan, Priyank
    Pooleri, Ginil Kumar
    Kalavampara, Sanjeevan, V
    Bhat, Sanjay
    Thomas, Appu
    Sundar, Praveen
    Laddha, Abhishek
    [J]. INDIAN JOURNAL OF UROLOGY, 2018, 34 (04) : 260 - 267
  • [5] Lymph node yield at radical prostatectomy is a predictor of biochemical recurrence-free survival (BFS) in high-risk prostate cancer patients
    Siriwardana, A.
    Thompson, J.
    Ting, F.
    Delprado, W.
    Brenner, P.
    Ende, D.
    Kooner, R.
    O'Neill, G.
    Yuen, C.
    Tiwari, S.
    Haynes, A-M
    Stricker, P.
    [J]. BJU INTERNATIONAL, 2017, 119 : 78 - 78
  • [6] Biochemical Recurrence-free Survival After Robotic-assisted Laparoscopic vs Open Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer
    Ritch, Chad R.
    You, Chaochen
    May, Alexandra T.
    Herrell, S. Duke
    Clark, Peter E.
    Penson, David F.
    Chang, Sam S.
    Cookson, Michael S.
    Smith, Joseph A., Jr.
    Barocas, Daniel A.
    [J]. UROLOGY, 2014, 83 (06) : 1309 - 1315
  • [7] Predictive factors for short-term biochemical recurrence-free survival after robot-assisted laparoscopic radical prostatectomy in high-risk prostate cancer patients
    Kanehira, Mitsugu
    Takata, Ryo
    Ishii, Shuhei
    Ito, Akito
    Ikarashi, Daiki
    Matsuura, Tomohiko
    Kato, Yoichiro
    Obaral, Wataru
    [J]. INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2019, 24 (09) : 1099 - 1104
  • [8] Predictive factors for short-term biochemical recurrence-free survival after robot-assisted laparoscopic radical prostatectomy in high-risk prostate cancer patients
    Mitsugu Kanehira
    Ryo Takata
    Shuhei Ishii
    Akito Ito
    Daiki Ikarashi
    Tomohiko Matsuura
    Yoichiro Kato
    Wataru Obara
    [J]. International Journal of Clinical Oncology, 2019, 24 : 1099 - 1104
  • [9] TWIST overexpression predicts biochemical recurrence-free survival in prostate cancer patients treated with radical prostatectomy
    Raatikainen, Sami
    Aaltomaa, Sirpa
    Palvimo, Jorma J.
    Karja, Vesa
    Soini, Ylermi
    [J]. SCANDINAVIAN JOURNAL OF UROLOGY, 2015, 49 (01) : 51 - 57
  • [10] Predictive factors of biochemical recurrence after radical prostatectomy for high-risk prostate cancer
    Murata, Yukiko
    Tatsugami, Katsunori
    Yoshikawa, Masahiro
    Hamaguchi, Masumitsu
    Yamada, Shigetomo
    Hayakawa, Yusuke
    Ueda, Kouhei
    Momosaki, Seiya
    Sakamoto, Naotaka
    [J]. INTERNATIONAL JOURNAL OF UROLOGY, 2018, 25 (03) : 284 - 289