Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA Project

被引：0

作者：

Martin-Martinez, M. A. ^{[1
]}

Castaneda, S. ^{[2
]}

Gonzalez-Juanatey, C. ^{[3
]}

Sanchez-Alonso, F. ^{[1
]}

Garcia-Gomez, C. ^{[4
]}

Lopez-Gonzalez, R. ^{[5
]}

Babio-Herraiz, J. ^{[6
]}

Juan-Mas, A. ^{[7
]}

Moreno-Gil, M. P. ^{[8
]}

Sanchez-Gonzalez, C. O. ^{[9
]}

Romera-Baures, M. ^{[10
]}

Pinto-Tasende, J. A. ^{[11
]}

Tornero-Molina, J. ^{[12
]}

Fabregas-Canales, D. ^{[13
]}

Llorca, J. ^{[14
,15
]}

Gonzalez-Gay, M. A. ^{[16
,17
,18
]}

Gonzalez de Rabago, Eugenia ^{[19
]}

Blanco Morales, Elena Alonso ^{[19
]}

Fernandez Lopez, J. Carlos ^{[19
]}

Oreiro Villar, Natividad ^{[19
]}

Atanes Sandoval, Antonio ^{[19
]}

Blanco Garcia, Francisco J. ^{[19
]}

Alegre De Miquel, Cayetano ^{[20
]}

Gonzalez Fernandez, Maria J. ^{[20
]}

Huguet Codina, Ramon ^{[20
]}

Yoldi, Beatriz ^{[20
]}

Ramentol, Mercedes ^{[20
]}

Avila, Gabriela ^{[21
]}

Marsal Barril, Sara ^{[21
]}

Quesada, Estefania ^{[21
]}

Steiner, Martina ^{[22
]}

Munoz, Santiago ^{[22
]}

Cobo, Tatiana ^{[22
]}

Gamero, Fernando ^{[23
]}

Garcia Toron, Jose ^{[23
]}

Espino, Pilar ^{[24
]}

Ros, Inmaculada ^{[24
]}

Ibanez, Monica ^{[24
]}

Murillo, Claudia ^{[24
]}

Sanmarti, Raimon ^{[25
]}

Berman, Horacio ^{[25
]}

Cabrera, Sonia ^{[25
]}

Ruiz, Virginia ^{[25
]}

Fontsere Paton, Oscar ^{[26
]}

Fernandez Gutierrez, Benjamin ^{[26
]}

Abasolo, Lydia ^{[26
]}

Pina, Jose M.

Nolla, Joan M. ^{[27
]}

Garcia Arias, Miriam ^{[28
]}

Garcia Vadillo, Jesus A. ^{[28
]}

机构：

[1] Spanish Soc Rheumatol, Res Unit, Madrid, Spain

[2] Hosp Univ Princesa, Div Rheumatol, IIS Princesa, Madrid, Spain

[3] Hosp Lucus Augusti, Div Cardiol, Lugo, Spain

[4] Consorci Sanitari Terrassa, Div Rheumatol, Barcelona, Spain

[5] Hosp Gen de la Virgen Concha, Div Rheumatol, Zamora, Spain

[6] Hosp Cabuenes, Div Rheumatol, Gijon, Spain

[7] Hosp Son Llatzer, Div Rheumatol, Palma de Mallorca, Spain

[8] Hosp San Pedro de Alcantara, Div Rheumatol, Caceres, Spain

[9] Hosp Sureste, Div Rheumatol, Madrid, Spain

[10] Bellvitge Hosp, Div Rheumatol, Barcelona, Spain

[11] Complejo Hosp A Coruna, Div Rheumatol, Xubias De Arriba, A Coruna, Spain

[12] Hosp Univ Guadalajara, Div Rheumatol, Guadalajara, Spain

[13] Hosp Barbastro, Div Rheumatol, Huesca, Spain

[14] Univ Cantabria, Sch Med, Div Epidemiol & Computat Biol, Santander, Spain

[15] CIBER Epidemiol & Salud Publ CIBERESP, Santander, Spain

[16] Univ Cantabria, Hosp Univ Marques de Valdecilla, Div Rheumatol, Santander, Spain

[17] IDIVAL, Div Rheumatol, Epidemiol Genet & Atherosclerosis Res Grp System, Santander, Spain

[18] Univ Witwatersrand, Cardiovasc Pathophysiol & Genom Res Unit, Fac Hlth Sci, Sch Physiol, Johannesburg, South Africa

[19] Complejo Hosp A Coruna, Xubias De Arriba, A Coruna, Spain

[20] Inst Dexeus, Barcelona, Spain

[21] Hosp Univ Vall dHebron, Barcelona, Spain

[22] Hosp Infanta Sofia, Madrid, Spain

[23] Hosp S Pedro de Alcantara, Caceres, Spain

[24] Hosp Son Llatzer, Palma de Mallorca, Spain

[25] Hosp Clin Barcelona, Barcelona, Spain

[26] Hosp Clin Univ San Carlos, Madrid, Spain

[27] Hosp Univ Bellvitge, Barcelona, Spain

[28] Hosp Univ De La Princesa, Madrid, Spain

[29] Hosp Reg Univ Carlos Haya, Malaga, Spain

[30] Hosp Virgen de la Salud, Toledo, Spain

[31] Hosp Ramon & Cajal, Madrid, Spain

[32] Hosp Univ Miguel Servet, Zaragoza, Spain

[33] Hosp Dr Negrin, Las Palmas Gran Canaria, Spain

[34] Hosp Gregorio Maranon, Madrid, Spain

[35] Hosp Univ Salamanca, Salamanca, Spain

[36] Hosp Univ Marques de Valdecilla, Santander, Spain

[37] Hosp Marina Baixa, Alicante, Spain

[38] Hosp San Rafael, Barcelona, Spain

[39] Hosp Gen Univ, Valencia, Spain

[40] Inst Poal, Barcelona, Spain

[41] Hosp Univ Puerta Hierro, Madrid, Spain

[42] Hosp Clin Univ San Cecilio, Granada, Spain

[43] Hosp Santiago Apostol, Vitoria, Spain

[44] Hosp Viladecans, Barcelona, Spain

[45] Hosp Gen Albacete, Albacete, Spain

[46] Hosp Mutua Terrassa, Terrassa, Spain

[47] Hosp Ntra Sra Candelaria, Santa Cruz De Tenerife, Spain

[48] Hosp Univ Canarias, Tenerife, Spain

[49] Hosp Univ Valme, Seville, Spain

[50] Inst Prov Rehabil, Madrid, Spain

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2019年 / 37卷 / 05期

关键词：

incidence; cardiovascular diseases; rheumatoid arthritis; ankylosing spondylitis; psoriatic arthritis; cohort study; CARMA project; CORONARY-ARTERY CALCIFICATION; PSORIATIC-ARTHRITIS PATIENTS; ANKYLOSING-SPONDYLITIS; RISK STRATIFICATION; CAROTID ULTRASOUND; SUBCLINICAL ATHEROSCLEROSIS; MORTALITY; MORBIDITY; COMORBIDITIES; METAANALYSIS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). Methods Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2.5 years from the start of the project. Weibull proportional hazard model was used to calculate hazard ratio (HR) and 95% confidence interval (95% CI) of the risk factors. Results 2595 (89.1%) patients completed the 2.5 years of follow-up visit. Cumulative incidence of CVE in patients with CIRD was 15.30 cases per 1000 patients (95% CI: 12.93-17.67), being higher in the subgroup with AS; 22.03 (95% CI: 11.01-33.04). Patients with AS (HR: 4.11; 95% CI: 1.07-15.79), those with older age (HR: 1.09; 95% CI: 1.05-1.13), systolic hypertension (HR: 1.02; 95% CI: 1.00-1.04) and long duration of the disease (HR: 1.07; 95% CI: 1.03-1.12) were at higher risk of first CVE during the 2.5 years of follow-up. In contrast, female gender was a protective factor (HR: 0.43; 95% CI: 0.18-1.00). Conclusion Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older

引用

页码：731 / 739

页数：9

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[1] INCIDENCE OF FIRST CARDIOVASCULAR EVENT IN SPANISH PATIENTS WITH CHRONIC INFLAMMATORY RHEUMATIC DISEASES: PROSPECTIVE DATA FROM THE CARMA PROJECT
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Torrente Segarra, V.
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