Chiral aminoalcohol NOBIN for instantaneous chirality control of racemic but tropos BIPHEP-Rh(I)-complexes:: highly enantioselective ene-type cyclization of 1,6-enynes catalyzed by the Rh(I)-complexes without use of acid

被引：17

作者：

Mikami, Koichi ^{[1
]}

Kataoka, Shohei ^{[1
]}

Wakabayashi, Kazuki ^{[1
]}

Aikawa, Kohsuke ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Tokyo 1528552, Japan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 36期

关键词：

D O I：

10.1016/j.tetlet.2006.06.179

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tropos (chirally flexible) or atropos (chirally rigid) nature of BIPHEP-Rh complexes critically depends on amines and alcohols complexed. The BIPHEP-Rh complex with aminoalcohol NOBIN is significantly tropos and can be chirally controlled by aminoalcohol NOBIN instantaneously even at room temperature. The BIPHEP Rh/NOBIN complex thus controlled can be used as an asymmetric catalyst to give higher enantioselectivity (up to 98% ee) and yield in ene-type cyclization of 1,6-enynes without use of acid. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6361 / 6364

页数：4

共 2 条

[1] Racemic but Tropos (chirally flexible) BIPHEP ligands for Rh(I)-complexes:: Highly enantioselective ene-type cyclization of 1,6-enynes
Mikami, K
Kataoka, S
Yusa, Y
Aikawa, K
[J]. ORGANIC LETTERS, 2004, 6 (21) : 3699 - 3701
[2] Highly enantioselective hydrosilylation/cyclization of 1,6-enynes catalyzed by rhodium(I) complexes of spiro diphosphines
Fan, Bao-Min
Xie, Jian-Hua
Li, Shen
Wang, Li-Xin
Zhou, Qi-Lin
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (08) : 1275 - 1277

← 1 →