Transforming growth factor-beta:: An important role in CD4+ CD25+ regulatory T cells and immune tolerance

被引：61

作者：

Zhang, Lianjun

Yi, Huanfa

Xia, Xue-Pei

Zhao, Yong

机构：

[1] Chinese Acad Sci, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Transplantat Biol Res Div, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

[3] Beijing Haidian Hosp, Dept Endocrinol, Beijing, Peoples R China

[4] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68182 USA

来源：

AUTOIMMUNITY | 2006年 / 39卷 / 04期

关键词：

transforming growth factor-beta; Foxp3; regulatory T cells; immune tolerance;

D O I：

10.1080/08916930600753903

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transforming growth factor-beta (TGF-beta) protein family is highly evolutionarily conserved and they have been implicated in many biological processes. Also, TGF-beta can exert pivotal functions in the immune system. It is widely accepted that regulatory T cells (Treg cells) play an important role in the maintenance of the immune homeostasis, but the underlying molecular mechanisms through which they can gain and/or perform suppressive functions in an active way remains to be defined. Though the engagement of TGF-beta in the Treg cells has been discounted for a period of time, an emerging body of data has established a close link between Treg cells and TGF-beta, as TGF-beta has been demonstrated to induce the expression of Foxp3, which acts as a master regulator for the development and function of Treg cells. We will, herein, focus on the crucial role of TGF-beta signaling in Treg cell biology and summarize the current studies regarding TGF-beta in the generation and function of CD4 + CD25 + Treg cells both in vivo and in vitro .

引用

页码：269 / 276

页数：8

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