Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report

被引：16
|
作者：
Zerpa, O
Blanco, B
Kannee, C
Ulrich, M
Sindermann, H
Engel, J
Convit, J
机构：
[1] Minist Hlth & Social Dev, Inst Biomed, Caracas 1010A, Venezuela
[2] Cent Univ Venezuela, Caracas, Venezuela
[3] Zentaris GmbH, Clin Res, Frankfurt, Germany
来源：
INTERNATIONAL JOURNAL OF DERMATOLOGY | 2006年 / 45卷 / 06期
关键词：
D O I：
10.1111/j.1365-4632.2006.02751.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine. Methods The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently. Results Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed. Conclusions The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.
引用
收藏
页码：751 / 753
页数：3
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