Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity

被引：3
|
作者：
Chernikova, I. B. [1 ]
Khursan, S. L. [1 ]
Eropkin, M. Yu. [2 ]
Yunusov, M. S. [1 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Sci Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia
[2] Minist Healthcare Russian Federat, Res Inst Influenza, 15-17 Prof Popova St, St Petersburg 197376, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 02期
关键词：
5-fluorouracil; 5-chloro-5-fluoro-6-hydroxy-5; 6-dihydrouracil; antiviral activity; MYELOPEROXIDASE; 5-CHLOROURACIL;
D O I：
10.1007/s11094-019-01962-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
5-Chloro-5-fluoro-6-alkoxypyrimidines were synthesized via Cl-2 chlorination of 5-fluorouracil and 1,3-dimethyl-5-fluorouracil in various alcohols and were screened for antiviral activity. High antiviral activity was found for 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil against RS virus and human flu viruses A/H3N2 and A/H1N1pdm09.
引用
收藏
页码：108 / 112
页数：5
相关论文
共 50 条
  • [1] Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity
    I. B. Chernikova
    S. L. Khursan
    M. Yu. Eropkin
    M. S. Yunusov
    Pharmaceutical Chemistry Journal, 2019, 53 : 108 - 112
  • [2] REGIO AND STEREOSPECIFITY OF SOLVENT PHOTOADDITION TO 5-FLUOROURACIL AND 1,3-DIMETHYL-5-FLUOROURACIL
    ZUPANCIC, N
    ZUPAN, M
    SKET, B
    COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1984, 49 (07) : 1592 - 1599
  • [3] REGIO AND STEREOSPECIFICITY OF SOLVENT PHOTOADDITION TO 5-FLUOROURACIL AND 1,3-DIMETHYL-5-FLUOROURACIL
    ZUPANCIC, N
    ZUPAN, M
    SKET, B
    JOURNAL OF FLUORINE CHEMISTRY, 1983, 23 (05) : 483 - 483
  • [4] IMPROVED SYNTHESIS OF 5-FLUOROURACIL-6-C-14
    PERRY, CW
    BURGER, W
    BADER, GJ
    LIEBMAN, AA
    JOURNAL OF LABELLED COMPOUNDS, 1975, 11 (04): : 583 - 589
  • [5] GENERAL METHOD FOR SYNTHESIS OF 5-FLUOROURACIL AND 5-FLUOROURACIL DERIVATIVES
    SCHUMAN, PD
    WESTMORE.G
    ANDERSON, R
    WARNER, D
    TARRANT, P
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1971, (NSEP): : 20 - &
  • [6] The Synthesis of 6-Alkyl-5-Fluorouracil Derivatives
    Chinese Chemical Letters, 2000, (11) : 967 - 970
  • [7] The synthesis of 6-alkyl-5-fluorouracil derivatives
    You, JZ
    Chen, SY
    Chen, YZ
    CHINESE CHEMICAL LETTERS, 2000, 11 (11) : 967 - 970
  • [8] Synthesis and antitumor activity of 5-fluorouracil derivatives
    Ozaki, S
    MEDICINAL RESEARCH REVIEWS, 1996, 16 (01) : 51 - 86
  • [9] 5-FLUOROURACIL DERIVATIVES .11. SYNTHESIS OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL METABOLITES
    OZAKI, S
    WATANABE, Y
    NAGASE, T
    IKE, Y
    MORI, H
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1986, 34 (02) : 893 - 896
  • [10] SYNTHESIS OF 5-FLUOROURACIL DERIVATIVES CONTAINING AN INHIBITOR OF 5-FLUOROURACIL DEGRADATION
    HIROHASHI, M
    KIDO, M
    YAMAMOTO, Y
    KOJIMA, Y
    JITSUKAWA, K
    FUJII, S
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (09) : 1498 - 1506
12345