G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications

被引：211
|
作者：
Chuang, TT [1 ]
Iacovelli, L [1 ]
Sallese, M [1 ]
DeBlasi, A [1 ]
机构：
[1] IST RIC FARMACOL MARIO NEGRI,CONSORZIO MARIO NEGRI SUD,LAB MOL BIOL & PHARMACOL RECEPTORS,I-66030 SANTA MARIA IMBAR,ITALY
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1996年 / 17卷 / 11期
关键词：
D O I：
10.1016/S0165-6147(96)10048-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitizaton, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC). In this review, Tsu Tshen Chuang and colleagues discuss evidence to show that PKA and PKC can modify the functional state of the G protein-coupled receptor kinases/arrestin homologous desensitization machinery, providing a navel level of cross-talk in signal transduction. Studies on regulation of G protein-coupled receptor kinases and arrestins confirm that the functional state of this machinery may have important consequences for cellular responsiveness and may represent new targets for therapeutic strategies.
引用
收藏
页码：416 / 421
页数：6
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