Puzzling through fragment-based drug design

被引：32
|
作者：
Hajduk, Philip J. [1 ]
机构：
[1] Abbott Labs, Dept Adv Technol, Abbott Pk, IL 60064 USA
来源：
NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 12期
关键词：
D O I：
10.1038/nchembio1206-658
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fragment-based drug design capitalizes on the modular binding of low-molecular-weight, low-affinity ligands. However, the deconstruction of lead-like inhibitors into putative fragments reveals the surprising complexity of dealing with low-affinity leads, thereby challenging oversimplification of these leads and highlighting the richness of their chemical diversity and molecular recognition.
引用
收藏
页码：658 / 659
页数：2
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