Mechanisms by which exercise training benefits patients with heart failure

被引：98

作者：

Crimi, Ettore ^{[1
]}

Ignarro, Louis J. ^{[2
]}

Cacciatore, Francesco ^{[3
]}

Napoli, Claudio ^{[4
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA 02114 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[3] Cardiovasc Rehabil Fdn Salvatore Mauge, IRCCS, Ist Sci Telese Terme & Campoli BN, San Giovanni Rotondo, Italy

[4] Univ Naples 2, Sch Med 1, Dept Gen Pathol, Clin Pathol & Excellence Res Ctr Cardiovasc Dis, Naples, Italy

来源：

NATURE REVIEWS CARDIOLOGY | 2009年 / 6卷 / 04期

关键词：

NITRIC-OXIDE SYNTHASE; LEFT-VENTRICULAR FUNCTION; QUALITY-OF-LIFE; SKELETAL-MUSCLE METABOLISM; SYMPATHETIC-NERVE ACTIVITY; BRAIN NATRIURETIC PEPTIDE; CORONARY-ARTERY-DISEASE; FAILING HUMAN HEART; FACTOR-I EXPRESSION; PHYSICAL-ACTIVITY;

D O I：

10.1038/nrcardio.2009.8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical consequences of heart failure are fatigue, dyspnea, and progressive impairment of exercise tolerance. regular exercise training is associated with health-improving effects. in patients with stable heart failure, exercise training can relieve symptoms, improve exercise capacity and quality of life, as well as reduce hospitalization and, to some extent, risk of mortality. Progressive exercise training is associated with pulmonary, cardiovascular, and skeletal muscle metabolic adaptations that increase oxygen delivery and energy production. This review focuses on current knowledge of mechanisms by which progressive and moderate exercise training can have sustained beneficial effects on patients with heart failure.

引用

页码：292 / 300

页数：9

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Francesco Cacciatore
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