Use of snus and risk for cardiovascular disease: results from the Swedish Twin Registry

被引:36
|
作者
Hansson, J. [1 ]
Pedersen, N. L. [2 ]
Galanti, M. R. [1 ]
Andersson, T. [3 ,4 ]
Ahlbom, A. [4 ]
Hallqvist, J. [1 ,5 ]
Magnusson, C. [1 ]
机构
[1] Karolinska Inst, Dept Publ Hlth Sci, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden
[3] Stockholm Cty Council, Stockholm Ctr Publ Hlth, Div Epidemiol, Stockholm, Sweden
[4] Karolinska Inst, Inst Environm Med, Dept Epidemiol, S-17176 Stockholm, Sweden
[5] Uppsala Univ, Div Publ Hlth & Caring Sci, Uppsala, Sweden
基金
瑞典研究理事会;
关键词
cardiovascular disease; ischemic heart disease; smokeless tobacco; snus; stroke; SMOKELESS TOBACCO USE; MIDDLE-AGED MEN; LONG-TERM USE; MOIST SNUFF; MYOCARDIAL-INFARCTION; HARM REDUCTION; PUBLIC-HEALTH; ATHEROSCLEROSIS; SMOKING; SWEDEN;
D O I
10.1111/j.1365-2796.2009.02081.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To study the association between snus use and the risk for cardiovascular disease, i.e. ischemic heart disease and stroke. Cohort study. Sweden. Sixteen thousand six hundred and forty-two male Swedish twins participating in the Screening Across the Lifespan Twin Study, conducted in 1998-2002, were followed for incident cardiovascular disease. Participants were without a history of cardiovascular disease at baseline and incident cases were identified via the Swedish Cause of Death Register and Hospital Discharge Register. Overall, there was no association between use of snus and risk for cardiovascular disease. Current snus users, without a smoking history, had a relative risk of 1.00 (95% confidence interval 0.69-1.46) for cardiovascular disease as compared to non users. Corresponding relative risks for ischemic heart disease and stroke were 0.85 (95% confidence interval 0.51-1.41) and 1.18 (95% confidence interval 0.67-2.08), respectively. In smoking adjusted models, risk estimates for ischemic heart disease in relation to snus use were all close to unity regardless of timing or intensity of snus use. However, current heavy snus users (consuming more than four cans week(-1)) had a relative risk for stroke of 1.75 (95% confidence interval 0.95-3.21). These data do not support any strong association between snus use and risk for cardiovascular disease.
引用
收藏
页码:717 / 724
页数:8
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