SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

被引：19
|
作者：
Luque-Michel, Edurne [1 ,2 ]
Lemaire, Laurent [3 ,4 ]
Blanco-Prieto, Maria J. [1 ,2 ]
机构：
[1] Univ Navarra, Sch Pharm, Dept Pharm & Pharmaceut Technol, C Irunlarrea 1, Pamplona 31008, Spain
[2] Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain
[3] Univ Angers, Micro & Nanomed Translat MINT, CNRS 6021, INSERM UMR S 1066, 4 Rue Larrey, F-49933 Angers, France
[4] Univ Angers, PRISM Plateforme Rech Imagerie & Spect Metabol, 4 Rue Larrey, F-49933 Angers, France
来源：
DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2021年 / 11卷 / 02期
关键词：
Tween; 80; MRI; Tumor doubling time; Glioma; U87-MG; PLGA; SPION;
D O I：
10.1007/s13346-020-00880-8
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Glioma is a type of cancer with a very poor prognosis with a survival of around 15 months in the case of glioblastoma multiforme (GBM). In order to advance in personalized medicine, we developed polymeric nanoparticles (PNP) loaded with both SPION (superparamagnetic iron oxide nanoparticles) and doxorubicin (DOX). The former being used for its potential to accumulate the PNP in the tumor under a strong magnetic field and the later for its therapeutic potential. The emulsion solvent and evaporation method was selected to develop monodisperse PNP with high loading efficiency in both SPION and DOX. Once injected in mice, a significant accumulation of the PNP was observed within the tumoral tissue under static magnetic field as observed by MRI leading to a reduction of tumor growth rate.
引用
收藏
页码：515 / 523
页数：9
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