Benzimidazole CB2 agonists: Design, synthesis and SAR

被引：20
|
作者：
Nanda, Kausik K. [1 ]
Henze, Darrell A. [2 ]
Della Penna, Kimberly [2 ]
Desai, Reshma [2 ]
Leitl, Michael [2 ]
Lemaire, Wei [2 ]
White, Rebecca B. [3 ]
Yeh, Suzie [3 ]
Brouillette, Janine N. [4 ]
Hartman, George D. [1 ]
Bilodeau, Mark T. [1 ]
Trotter, B. Wesley [5 ]
机构：
[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA
[2] Merck Res Labs, Dept Pain Res, West Point, PA USA
[3] Merck Res Labs, Dept Drug Metab & Pharmacokinet, West Point, PA USA
[4] Merck Res Labs, Dept Struct Elucidat, West Point, PA USA
[5] Merck Res Labs, Dept Med Chem, Boston, MA USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 04期
关键词：
CB2; agonist; Cannabinoid; 2; receptor; Benzimidazole; CANNABINOID RECEPTOR; PHARMACOLOGY; LOCALIZATION; EXPRESSION; LIGANDS; BRAIN;
D O I：
10.1016/j.bmcl.2013.12.068
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1218 / 1221
页数：4
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