Fundamental equation of the dual flow rate-solvent gradient elution in liquid chromatography

被引：7
|
作者：
Papachristos, Kostas [1 ]
Nikitas, Panos [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Dept Chem, Phys Chem Lab, Thessaloniki 54124, Greece
来源：
JOURNAL OF CHROMATOGRAPHY A | 2009年 / 1216卷 / 12期
关键词：
Liquid chromatography; Fundamental equation; Dual-mode gradient elution; Flow programming;
D O I：
10.1016/j.chroma.2009.01.087
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
An alternative expression of the fundamental equation of multi-mode gradient elution involving simultaneous changes in mobile phase composition and flow rate is derived using simple kinetic arguments and graphic interpretation. The new expression consists of a system of two integral equations and provides an easy and direct way of predicting retention times under dual-mode gradient conditions. (c) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：2601 / 2604
页数：4
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