Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration

被引：115

作者：

Toh, Wei Seong ^{[1
,2
]}

Foldager, Casper Bindzus ^{[3
]}

Pei, Ming ^{[4
]}

Hui, James Hoi Po ^{[2
,5
]}

机构：

[1] Natl Univ Singapore, Fac Dent, Singapore 119083, Singapore

[2] Natl Univ Singapore, Inst Life Sci, Tissue Engn Program, Singapore 117510, Singapore

[3] Aarhus Univ Hosp, Orthopaed Res Lab, DK-8000 Aarhus C, Denmark

[4] W Virginia Univ, Dept Orthopaed, Stem Cell & Tissue Engn Lab, Morgantown, WV 26506 USA

[5] Natl Univ Singapore, Natl Univ Hlth Syst, Therapeut Tissue Engn Lab, Dept Orthopaed Surg,Cartilage Repair Program, Singapore 119288, Singapore

来源：

STEM CELL REVIEWS AND REPORTS | 2014年 / 10卷 / 05期

关键词：

Stem cells; Mesenchymal stem cells; Secretome; Extracellular matrix; Cartilage; Biomaterials; Tissue regeneration; Tissue engineering; AUTOLOGOUS CHONDROCYTE IMPLANTATION; DECELLULARIZED ADIPOSE-TISSUE; NUCLEUS PULPOSUS CELLS; MARROW STROMAL CELLS; EXTRACELLULAR-MATRIX; IN-VITRO; CHONDROGENIC DIFFERENTIATION; ARTICULAR-CARTILAGE; CULTURE-CONDITIONS; PROGENITOR CELLS;

D O I：

10.1007/s12015-014-9526-z

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration.

引用

页码：686 / 696

页数：11

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