Management of brain metastases in melanoma

Melanoma is the third malignant cancer after breast and lung cancer in terms of the incidence of brain metastases. Currently, brain metastases are diagnosed in asymptomatic patients using radiological examinations as a part of the follow-up or qualification for systemic treatment. Treatment of melanoma patients with brain metastases is currently one of the biggest challenges in caring for advanced melanoma patients. The aim of this paper is to provide a multidisciplinary guide to diagnostic and therapeutic management of this group of patients. Treatment of melanoma patients with brain metastases includes local treatment and/or systemic therapy as well as symptomatic treatment, depending on the clinical situation. Therapeutic decisions should be made in teams, which should include at least a clinical oncologist, neurosurgeon, and radiation oncologist.