Smart Mesoporous Silica Nanoparticles for Protein Delivery

被引：55
|
作者：
Liu, Hai-Jun [1 ]
Xu, Peisheng [1 ]
机构：
[1] Univ South Carolina, Dept Discovery & Biomed Sci, Coll Pharm, 715 Sumter, Columbia, SC 29208 USA
来源：
NANOMATERIALS | 2019年 / 9卷 / 04期
基金：
美国国家卫生研究院;
关键词：
mesoporous silica nanoparticle; protein delivery; controlled release; stimulus responsive MSN; RESPONSIVE CONTROLLED-RELEASE; SUPPORTED LIPID-BILAYERS; DRUG-DELIVERY; PORE-SIZE; IN-VITRO; INTRACELLULAR DELIVERY; PARTICLE-SIZE; CELL-MEMBRANE; SURFACE; PEGYLATION;
D O I：
10.3390/nano9040511
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting the loading of protein into MSN and general strategies for targeted delivery and controlled release of proteins with MSN. Additionally, we also give an outlook for the remaining challenges in the clinical translation of protein-loaded MSNs.
引用
收藏
页数：23
相关论文
共 50 条
  • [1] Mesoporous silica nanoparticles for the design of smart delivery nanodevices
    Colilla, Montserrat
    Gonzalez, Blanca
    Vallet-Regi, Maria
    [J]. BIOMATERIALS SCIENCE, 2013, 1 (02) : 114 - 134
  • [2] Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin
    Akhilesh Kumar Mishra
    Himanshu Pandey
    Vishnu Agarwal
    Pramod W. Ramteke
    Avinash C. Pandey
    [J]. Journal of Nanoparticle Research, 2014, 16
  • [3] Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin
    Mishra, Akhilesh Kumar
    Pandey, Himanshu
    Agarwal, Vishnu
    Ramteke, Pramod W.
    Pandey, Avinash C.
    [J]. JOURNAL OF NANOPARTICLE RESEARCH, 2014, 16 (08)
  • [4] Mesoporous Silica Nanoparticles for Protein Protection and Delivery
    Xu, Chun
    Lei, Chang
    Yu, Chengzhong
    [J]. FRONTIERS IN CHEMISTRY, 2019, 7
  • [5] Smart drug delivery: Capping strategies for mesoporous silica nanoparticles
    Nik, Amirala Bakhshian
    Zare, Hossein
    Razavi, Seyedsahameddin
    Mohammadi, Hesameddin
    Ahmadi, Pooya Torab
    Yazdani, Narges
    Bayandori, Mehrdad
    Rabiee, Navid
    Mobarakeh, Jalal Izadi
    [J]. MICROPOROUS AND MESOPOROUS MATERIALS, 2020, 299
  • [6] ROS responsive mesoporous silica nanoparticles for smart drug delivery: A review
    Daund, Varsha
    Chalke, Siddhi
    Sherje, Atul P.
    Kale, Pravin P.
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 64
  • [7] Smart mesoporous silica nanoparticles for controlled-release drug delivery
    Karimi, Mahdi
    Mirshekari, Hamed
    Aliakbari, Masoumeh
    Sahandi-Zangabad, Parham
    Hamblin, Michael R.
    [J]. NANOTECHNOLOGY REVIEWS, 2016, 5 (02) : 195 - 207
  • [8] Smart Protein-Based Formulation of Dendritic Mesoporous Silica Nanoparticles: Toward Oral Delivery of Insulin
    Juere, Estelle
    Caillard, Romain
    Marko, Doris
    Del Favero, Giorgia
    Kleitz, Freddy
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2020, 26 (23) : 5195 - 5199
  • [9] Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery
    Dumontel, Bianca
    Conejo-Rodriguez, Veronica
    Vallet-Regi, Maria
    Manzano, Miguel
    [J]. PHARMACEUTICS, 2023, 15 (02)
  • [10] Mesoporous Silica Nanoparticles for Drug Delivery
    Manzano, Miguel
    Vallet-Regi, Maria
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (02)
12345