Assessment of Some Immune Parameters in Occupationally Exposed Nuclear Power Plant Workers: Flow Cytometry Measurements of T Lymphocyte Subpopulations and Immunoglobulin Determination

被引:8
|
作者
Gyuleva, Ilona Mihaylova [1 ]
Penkova, Kalina Ivanova [2 ]
Rupova, Ivanka Tankova [1 ]
Panova, Delyana Yonkova [1 ]
Djounova, Jana Nikolaeva [1 ]
机构
[1] Natl Ctr Radiobiol & Radiat Protect, Sofia 1606, Bulgaria
[2] Aleksandrovska Hosp, Sofia, Bulgaria
来源
DOSE-RESPONSE | 2015年 / 13卷 / 04期
关键词
immunology; ionizing radiation; low-dose effects; lymphocytes; immunoglobulin; STRESS-INDUCED CHANGES; LOW-DOSE RADIATION; ADHESION MOLECULES; IONIZING-RADIATION; SYSTEM; IRRADIATION; EXPRESSION; CELLS; MICE; INDUCTION;
D O I
10.1177/1559325815611901
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A 10-year survey of immune status of nuclear power plant (NPP) workers was assessed by cellular and humoral immune parameters. The cumulative doses of NPP workers were in the range of 0.06 to 766.36 mSv. The results did not show significant deviations in the studied parameters of cellular and humoral immunity, but a tendency of elevated values in CD3+4+ helper inducers cells, especially its CD4+62L+ subpopulation, regulatory CD4+25+ cells, CD8+28+ cytotoxic subpopulation, and immunoglobulin M, was established. The observed trend of the above-mentioned parameters could be interpreted by assumption that while the adaptation processes are dominated with low prevalence of T-helper (Th) 1 immune response to cumulative doses less than 100 mSv, a switch to Th-2 response occurred at doses above 100 mSv. The impact of a number of other confounding factors on the immune system does not allow definitive conclusions about the direct radiation-induced changes in immune parameters.
引用
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页数:11
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  • [1] ASSESSMENT OF SOME IMMUNE PARAMETERS IN OCCUPATIONALLY EXPOSED NUCLEAR POWER PLANTS WORKERS: FLOWCYTOMETRY MEASUREMENTS OF T, B, NK AND NKT CELLS
    Gyuleva, Ilona
    Panova, Delyana
    Djounova, Jana
    Rupova, Ivanka
    [J]. DOSE-RESPONSE, 2015, 13 (01): : 1 - 15