Carbon Ion Radiotherapy for Skull Base Chordoma

被引：68
|
作者：
Mizoe, Jun-etsu [1 ]
Hasegawa, Azusa [1 ]
Takagi, Ryo [1 ]
Bessho, Hiroki [1 ]
Onda, Takeshi [1 ]
Tsujii, Hirohiko [1 ]
机构：
[1] Res Ctr Charged Particle Therapy Hosp, Natl Inst Radiol Sci, Inage Ku, Chiba 2638555, Japan
来源：
SKULL BASE-AN INTERDISCIPLINARY APPROACH | 2009年 / 19卷 / 03期
关键词：
Chordoma; carbon ion radiotherapy; particle radiotherapy; skull base tumor; RADIATION-THERAPY; PROTON THERAPY; TUMORS; EXPERIENCE; PHOTON; BEAMS;
D O I：
10.1055/s-0028-1114295
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To present the results of the clinical study of carbon ion radiotherapy (CIRT) for skull base and paracervical spine tumors at the National Institute of Radiological Sciences in Chiba, Japan. Methods: The study is comprised of three protocols: a pilot study, a phase I/II dose escalation study, and a phase II study. All the patients were treated by 1.6 fractions for 4 weeks with total doses of 48.0, 52.8, 57.6, and 60.8 Gy equivalents (GyE). Results: As a result of the dose escalation study of CIRT for skull base tumors, a dose fractionation of 60.8 GyE/16 fractions for 4 weeks was decided as the recommended dose because of acceptable normal tissue reactions and good local tumor control. Conclusions: Preliminary results of the phase II clinical study of CIRT for skull base chordoma showed local control at 5 years at 100%, and normal tissues showed a mild reaction without any severe morbidity of important organs.
引用
收藏
页码：219 / 224
页数：6
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