Cellular immune response in patients with chronic hepatitis B virus infection

被引：22
|
作者：
Li, Xuefen [1 ]
Wang, Yiyin [1 ]
Chen, Yu [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China
来源：
MICROBIAL PATHOGENESIS | 2014年 / 74卷
基金：
中国国家自然科学基金;
关键词：
Hepatitis B; Cellular immune response; Clinical implications; REGULATORY T-CELLS; DENDRITIC CELLS; HBV INFECTION; KILLER-CELLS; NK CELLS; THERAPY; EXPRESSION; INNATE; IMMUNOPATHOGENESIS; RESTORATION;
D O I：
10.1016/j.micpath.2014.07.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatitis, cirrhosis and hepatocellular carcinoma caused by hepatitis B virus (HBV) infection has threatening human health seriously. As HBV is a kind of non-cytotoxic virus, host immune response plays a vital role in pathogenesis and clinical outcomes of hepatitis B. Multiple immune cells (e.g., including cytotoxic T lymphocytes, regulatory T cells, natural killer cells, dendritic cells) are important in the immune regulation of HBV infection. Therefore, focusing on the activation states of immune cells may provide new evidences and strategies for determining immune status of HBV infectors, monitoring progression of diseases and predicting efficacy of antiviral treatment. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：59 / 62
页数：4
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