Adipokines: A link between obesity and cardiovascular disease

被引：360
|
作者：
Nakamura, Kazuto [1 ]
Fuster, Jose J. [1 ]
Walsh, Kenneth [1 ]
机构：
[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA
来源：
JOURNAL OF CARDIOLOGY | 2014年 / 63卷 / 3-4期
基金：
美国国家卫生研究院;
关键词：
Cardiovascular disease; Adiponectin; Sfrp5; Leptin; TNE alpha; TUMOR-NECROSIS-FACTOR; ACTIVATED PROTEIN-KINASE; HUMAN ENDOTHELIAL-CELLS; FATTY-ACID OXIDATION; DIET-INDUCED OBESITY; SMOOTH-MUSCLE-CELL; C-REACTIVE PROTEIN; ADIPONECTIN STIMULATES ANGIOGENESIS; ADIPOSE-TISSUE INFLAMMATION; INDUCED INSULIN-RESISTANCE;
D O I：
10.1016/j.jjcc.2013.11.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity is a risk factor for various cardiovascular diseases including hypertension, atherosclerosis, and myocardial infarction. Recent studies aimed at understanding the microenvironment of adipose tissue and its impact on systemic metabolism have shed light on the pathogenesis of obesity-linked cardiovascular diseases. Adipose tissue functions as an endocrine organ by secreting multiple immune-modulatory proteins known as adipokines. Obesity leads to increased expression of pro-inflammatory adipokines and diminished expression of anti-inflammatory adipokines, resulting in the development of a chronic, low-grade inflammatory state. This adipokine imbalance is thought to be a key event in promoting both systemic metabolic dysfunction and cardiovascular disease. This review will focus on the adipose tissue microenvironment and the role of adipokines in modulating systemic inflammatory responses that contribute to cardiovascular disease. (C) 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：250 / 259
页数：10
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