Anti-tuberculosis drug resistance in Ethiopia: systematic review

被引：5
|
作者：
Weldegebreal, S. [1 ]
Mebrahtut, T. [2 ,3 ]
机构：
[1] Mekelle Univ, Coll Hlth Sci, Dept Pharm, Clin Pharm Unit, POB 231, Mekelle, Ethiopia
[2] Axum Univ, Coll Hlth Sci, Sch Med, Unit Biomed Sci, Axum, Ethiopia
[3] Axum Univ, Referral Hosp, Axum, Ethiopia
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2017年 / 21卷 / 01期
关键词：
anti-tuberculosis; drug resistance; Ethiopia; MYCOBACTERIUM-TUBERCULOSIS; ADDIS-ABABA; EPIDEMIOLOGY;
D O I：
10.5588/ijtld.16.0286
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
BACKGROUND: Resistance to anti-tuberculosis drugs threatens to undermine effective control of tuberculosis (TB). In areas with weak TB control and misuse of antituberculosis drugs, hotspots of multidrug-resistant TB (MDR-TB) have appeared. The aim of this review is to determine the prevalence rate of any anti-tuberculosis drug resistance, monoresistance and MDR-TB in Ethiopia. METHODS: A systematic review of the literature on any resistance, monoresistance and MDR-TB was conducted. RESULTS: Of the total 468 articles found using electronic search, 14 met the eligibility criteria and were included in the review. The prevalence rate of any drug resistance, polyresistance and MDR-TB was respectively 6.7-72.9%, 0-54% and 0-46%. A higher rate of streptomycin monoresistance (1.5-20.4%) was observed. CONCLUSION: The prevalence and distribution of drug-resistant TB remains a serious public health problem in Ethiopia. Rapid, advanced diagnostic tools should be introduced, along with strong treatment and follow-up strategies.
引用
收藏
页码：18 / 22
页数：5
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