Combined action of doxorubicin and gestagens on doxorubicin-sensitive and doxorubicin-resistant MCF-7 cells

被引：2
|
作者：
Sergeev, PV [1 ]
Semeikin, AV
Fedotcheva, TA
Samoilikov, RV
Kamernitskii, AV
Levina, IS
Rzheznikov, VM
Grinenko, GS
Korystov, YN
Ermakova, NV
Shaposhnikova, VV
Shimanovskii, NL
机构：
[1] Russian State Med Univ, Med & Biol Fac, Dept Mol Pharmacol & Radiobiol, Moscow, Russia
[2] Russian Acad Sci, Grp Chem Steroids & Oxylipins, ND Zelinskii Organ Chem Inst, Moscow, Russia
[3] Russian Acad Med Sci, Res Ctr Endocrinol, Moscow, Russia
[4] Russian Acad Sci, Inst Theoret & Expt Biophys, Lab Regulat Cell Proliferat & Death, Pushchino, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 05期
关键词：
multidrug resistance; P-glycoprotein; gestagens; doxorlibicin; MCF-7;
D O I：
10.1023/B:BEBM.0000017093.04390.a3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MT-f assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecigestone, and butagest in high concentrations (10(-5) M) potentiated the cytostatic action of doxorubicin in sensitive and resistant cells by 30-50%. Potentiation of the cytostatic effect produced by doxorubicin in sensitive cells is related to intrinsic cytotoxic activity of gestagens. In resistant cells these changes are associated with potentiation of the effect of doxorubicin.
引用
收藏
页码：460 / 463
页数：4
相关论文
共 50 条
  • [1] Combined Action of Doxorubicin and Gestagens on Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Cells
    P. V. Sergeev
    A. V. Semeikin
    T. A. Fedotcheva
    R. V. Samoilikov
    A. V. Kamernitskii
    I. S. Levina
    V. M. Rzheznikov
    G. S. Grinenko
    Yu. N. Korystov
    N. V. Ermakova
    V. V. Shaposhnikova
    N. L. Shimanovskii
    [J]. Bulletin of Experimental Biology and Medicine, 2003, 136 : 460 - 463
  • [2] Effect of doxorubicin on telomerase activity and apoptotic gene expression in doxorubicin-resistant and -sensitive MCF-7 cells
    Eskiocak, Ugur
    Iseri, Ozlem Darcansoy
    Kars, Meltem Demirel
    Bicer, Atilla
    Gunduz, Ufuk
    [J]. CHEMOTHERAPY, 2008, 54 (03) : 209 - 216
  • [3] RETRACTED: Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells (Retracted Article)
    Hong, Wei
    Shi, Hong
    Qiao, Mingxi
    Gao, Xiang
    Yang, Jie
    Tian, Chunlian
    Zhang, Dexian
    Niu, Shengli
    Liu, Mingchun
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 12 : 989 - 1007
  • [4] Effects of doxorubicin on telomerase and apoptosis in doxorubicin resistant and sensitive MCF-7 cells
    Eskiocak, U.
    Iseri, O. Darcansoy
    Kars, M. Demirel
    Bicer, A.
    Gunduz, U.
    [J]. FEBS JOURNAL, 2007, 274 : 156 - 156
  • [5] DNA DAMAGE AND CYTOTOXICITY OF MITOXANTRONE AND DOXORUBICIN IN DOXORUBICIN-SENSITIVE AND DOXORUBICIN-RESISTANT HUMAN COLON-CARCINOMA CELLS
    CAPOLONGO, L
    BELVEDERE, G
    DINCALCI, M
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1990, 25 (06) : 430 - 434
  • [6] Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells
    Wang, Xu
    Hui, Renjie
    Chen, Yun
    Wang, Wentao
    Chen, Yujiao
    Gong, Xiaohai
    Jin, Jian
    [J]. FRONTIERS IN PHARMACOLOGY, 2019, 10
  • [7] Oxidative phosphorylation and energy status in doxorubicin-sensitive and doxorubicin-resistant Guerin carcinoma
    Chekhun, VF
    Todor, IN
    Solyanik, GI
    Kulik, GI
    Tryndiak, VP
    [J]. EXPERIMENTAL ONCOLOGY, 2000, 22 (04): : 195 - 199
  • [8] FLUORESCENCE ANISOTROPY OF CELL-MEMBRANES OF DOXORUBICIN-SENSITIVE AND DOXORUBICIN-RESISTANT RODENT TUMORAL CELLS
    MONTAUDON, D
    VRIGNAUD, P
    LONDOSGAGLIARDI, D
    ROBERT, J
    [J]. CANCER RESEARCH, 1986, 46 (11) : 5602 - 5605
  • [9] DIFFERENCES IN LIPID-COMPOSITION OF DOXORUBICIN-SENSITIVE AND DOXORUBICIN-RESISTANT P388 CELLS
    RAMU, A
    GLAUBIGER, D
    WEINTRAUB, H
    [J]. CANCER TREATMENT REPORTS, 1984, 68 (04): : 637 - 641
  • [10] RETRACTION: Rational Design of Multifunctional Micelles Against Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Human Breast Cancer Cells (Retraction of Vol 12, Pg 989, 2017)
    Hong, W.
    Shi, H.
    Qiao, M.
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2022, 17 : 3055 - 3055
12345