Clinical manifestations and perinatal outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

被引:50
|
作者
Yee, Jeong [1 ]
Kim, Woorim [2 ]
Han, Ji Min [1 ]
Yoon, Ha Young [1 ]
Lee, Nari [1 ]
Lee, Kyung Eun [2 ]
Gwak, Hye Sun [1 ]
机构
[1] Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea
[2] Chungbuk Natl Univ, Coll Pharm, 660-1 Yeonje Ri, Cheongju 28160, South Korea
关键词
IMMUNE-SYSTEM;
D O I
10.1038/s41598-020-75096-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This systematic review and meta-analysis aimed to evaluate the impact of COVID-19 on pregnant women. We searched for qualified studies in PubMed, Embase, and Web of Science. The clinical characteristics of pregnant women with COVID-19 and their infants were reported as means and proportions with 95% confidence interval. Eleven studies involving with 9032 pregnant women with COVID-19 and 338 infants were included in the meta-analysis. Pregnant women with COVID-19 have relatively mild symptoms. However, abnormal proportions of laboratory parameters were similar or even increased, compared to general population. Around 30% of pregnant women with COVID-19 experienced preterm delivery, whereas the mean birth weight was 2855.9 g. Fetal death and detection of SARS-CoV-2 were observed in about 2%, whereas neonatal death was found to be 0.4%. In conclusion, the current review will serve as an ideal basis for future considerations in the treatment and management of COVID-19 in pregnant women.
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页数:7
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