Sigma-1 receptor knockout mice display a depressive-like phenotype

被引：147
|
作者：
Sabino, Valentina [1 ,2 ]
Cottone, Pietro [1 ,2 ]
Parylak, Sarah L. [1 ,2 ,4 ]
Steardo, Luca [3 ]
Zorrilla, Eric P. [1 ,2 ,4 ]
机构：
[1] Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Harold L Dorris Neurol Res Inst, La Jolla, CA 92037 USA
[3] Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, Rome, Italy
[4] Univ Calif San Diego, Grad Program Neurosci, La Jolla, CA 92093 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2009年 / 198卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Antidepressant; Neurosteroids; Sigma-1; Forced swim; CONDITIONED FEAR STRESS; FORCED SWIMMING TEST; BEHAVIORAL DESPAIR; ER STRESS; MOLECULAR-CLONING; BINDING-SITES; HIGH-AFFINITY; PC12; CELLS; NEUROSTEROIDS; INVOLVEMENT;
D O I：
10.1016/j.bbr.2008.11.036
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：472 / 476
页数：5
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