Effect of Platelet Releasate on Osteogenic Differentiation of Human Mesenchymal Bone Marrow Stem Cells

被引：8
|
作者：
Kosmacheva, S. M. [1 ]
Danilkovich, N. N. [1 ]
Shchepen', A. V. [1 ]
Ignatenko, S. I. [1 ]
Potapnev, M. P. [1 ]
机构：
[1] Republican Res & Pract Ctr Transfus & Med Biotech, Minsk, BELARUS
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 156卷 / 04期
关键词：
mesenchymal stem cells; human bone marrow; osteogenic differentiation; differentiation markers; platelet releasate; RICH PLASMA; GROWTH-FACTORS; STROMAL CELLS; TISSUE; PROLIFERATION; REGENERATION; DECREASE;
D O I：
10.1007/s10517-014-2396-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of platelet releasate on osteogenic differentiation of human mesenchymal BM stem cells. Histological staining and reverse transcription PCR analysis showed that addition of platelet releasate to osteogenic differentiation medium stimulated the formation of calcium ossificates and alkaline phosphatase and increased expression of osteopontin and alkaline phosphatase genes.
引用
收藏
页码：560 / 565
页数：6
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