Lewis Acid Mediated Intramolecular C-C Bond Formation of Alkyne-Epoxide Leading to Six-Membered Nitrogen and Oxygen Heterocycles

被引：20

作者：

Ghosh, Priya ^{[1
]}

Saha, Pipas ^{[1
]}

Bondalapati, Somasekhar ^{[1
]}

Indukuri, Kiran ^{[1
]}

Saikia, Anil K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 09期

关键词：

STEREOSELECTIVE-SYNTHESIS; CROSS-CYCLIZATION; FACILE SYNTHESIS; PRINS REACTION; BREVETOXIN-B; AZA-PRINS; DERIVATIVES; ENYNES; CARBOCYCLIZATION; CYCLOADDITIONS;

D O I：

10.1021/jo402550e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intramolecular C-C bond formation of oxygen- and nitrogen-tethered alkynes and epoxide mediated by Lewis acid under ambient conditions is described. A simple procedure for the synthesis of 3,6- and 5,6-dihydropyrans and 3,4-dehydropiperidines from acyclic building blocks in good yields without using any transition metal is shown.

引用

页码：4119 / 4124

页数：6

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